Document 0366
 DOCN  M9550366
 TI    Immunization of chimpanzees with recombinant gp160, but not infection
       with human immunodeficiency virus type 1, induces envelope-specific Th1
       memory cells.
 DT    9505
 AU    Mannhalter JW; Fischer MB; Wolf HM; Kupcu Z; Barrett N; Dorner F; Eder
       G; Eibl MM; Immuno AG, Vienna, Austria.
 SO    J Infect Dis. 1995 Feb;171(2):437-40. Unique Identifier : AIDSLINE
       MED/95146795
 AB    The human immunodeficiency virus (HIV) type 1 envelope protein
       (recombinant [r] gp160)-induced T cell lymphokine release pattern of
       chimpanzees immunized with HIVIIIB rpg160 tested and compared with
       rpg160-induced lymphokine releases of T cells from unimmunized,
       HIV-1-infected chimpanzees. The results showed that infection of
       chimpanzees with HIV-1 did not induce rgp160-specific memory T cells (as
       evidenced by the lack of Th1 and 2 type lymphokine releases after rgp160
       stimulation). In contrast, T cells of rgp160-immunized chimpanzees
       released Th1 type lymphokines upon stimulation with rgp160 of HIVIIIB,
       HIVMN, and HIVRF. release was comparable whether chimpanzees were
       immunized with rgp160 only or also challenged with HIV-1 and protected
       or not protected. Thus, rgp160 immunization leads to generation of Th1
       type memory cells. Whether Th1 type responses contribute to protection
       against HIV-1 infection has yet to be clarified.
 DE    Animal  Chimpansee troglodytes  Comparative Study  Gene Products,
       env/GENETICS/*IMMUNOLOGY  HIV Antibodies/*BIOSYNTHESIS  HIV
       Infections/*IMMUNOLOGY/PREVENTION & CONTROL  HIV-1/*IMMUNOLOGY
       Immunization  *Immunologic Memory  Leukocytes, Mononuclear/IMMUNOLOGY
       Lymphokines/BIOSYNTHESIS  Protein Precursors/GENETICS/*IMMUNOLOGY
       Recombinant Proteins/IMMUNOLOGY  Th1 Cells/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).