Document 0367
 DOCN  M9550367
 TI    Human cytomegalovirus DNA is present in CD45+ cells in semen from human
       immunodeficiency virus-infected patients.
 DT    9505
 AU    Rasmussen L; Morris S; Hamed K; Merigan TC; Center for AIDS Research,
       Stanford Univresity School of Medicine,; California 94305.
 SO    J Infect Dis. 1995 Feb;171(2):432-6. Unique Identifier : AIDSLINE
       MED/95146794
 AB    Human cytomegalovirus (CMV) DNA was detected and quantitated in both
       blood and semen cells from human immunodeficiency virus (HIV)-infected
       men with 100-800 CD4 cell counts/mm3. None of the 35 patients studied
       had demonstrable CMV DNA in mononuclear cells isolated from blood. Blood
       samples from 8 of these patients were cultured for CMV and found to be
       negative. About 30% of HIV-seropositive patients in the study group had
       > 100 copies of CMV in semen (range, > 100 to >10(6); mean,
       approximately 100,000). Persistent CMV infection was detected for > 8
       months in some patients with no obvious signs or symptoms of CMV
       disease. The CMV-infected cell in semen CD45+ and probably had Fc
       receptors. Mature spermatozoa were not a major reservoir of CMV
       infection.
 DE    *Antigens, CD45  Cell Separation  Cytomegalovirus
       Infections/COMPLICATIONS/*DIAGNOSIS  CD4 Lymphocyte Count  DNA,
       Viral/*ISOLATION & PURIF  Human  HIV Infections/COMPLICATIONS/*VIROLOGY
       Leukocytes, Mononuclear/VIROLOGY  Male  Polymerase Chain Reaction
       Semen/CYTOLOGY/*VIROLOGY  Spermatozoa/VIROLOGY  Support, U.S. Gov't,
       P.H.S.  Virus Shedding  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).