Document 0368
 DOCN  M9550368
 TI    Macrophages from human immunodeficiency virus-positive persons are
       defective in host defense against Histoplasma capsulatum.
 DT    9505
 AU    Chaturvedi S; Frame P; Newman SL; Department of Internal Medicine,
       University of Cincinnati College; of Medicine, Ohio.
 SO    J Infect Dis. 1995 Feb;171(2):320-7. Unique Identifier : AIDSLINE
       MED/95146777
 AB    The phagocytic and fungistatic activity of monocyte-derived macrophages
       from human immunodeficiency virus (HIV)-positive persons against
       Histoplasma capsulatum yeasts was determined. Macrophages from
       HIV-positive patients were profoundly deficient in their capacity to
       recognize and bind H. capsulatum, but ingestion of bound yeasts was
       normal. The binding of H. capsulatum by patient macrophages tended to
       decrease with a decrease in CD4+ T lymphocyte counts. Another major
       defect was that patient macrophages were more permissive for the
       intracellular growth of H. capsulatum. Macrophages from 22 of 58
       patients showed a > or = 2-fold increase in intracellular growth
       compared with control macrophages. Thus, in addition to defects in
       cell-mediated immunity caused by a loss of CD4+ T cells, macrophages
       from HIV-positive patients exhibit intrinsic defects in macrophage
       function against H. capsulatum that may contribute to the increased
       susceptibility of HIV-positive patients to disseminated histoplasmosis.
 DE    AIDS-Related Opportunistic Infections/ETIOLOGY  Cell Adhesion/IMMUNOLOGY
       CD4 Lymphocyte Count  Histoplasma/GROWTH & DEVELOPMENT/*IMMUNOLOGY
       Human  HIV Infections/*IMMUNOLOGY  Immunity, Cellular
       Macrophages/*IMMUNOLOGY  Monocytes/*IMMUNOLOGY  Phagocytosis/*IMMUNOLOGY
       Regression Analysis  Support, Non-U.S. Gov't  Support, U.S. Gov't,
       P.H.S.  JOURNAL ARTICLE

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