Document 0369
 DOCN  M9550369
 TI    Association between anti-CD4 antibodies and a decline in CD4+
       lymphocytes in human immunodeficiency virus type 1 seroconverters.
 DT    9505
 AU    Keay S; Wecksler W; Wasserman SS; Margolick J; Farzadegan H; University
       of Maryland School of Medicine (Division of Infectious; Diseases), Johns
       Hopkins School of Hygiene and Public Health,; Baltimore, MD.
 SO    J Infect Dis. 1995 Feb;171(2):312-9. Unique Identifier : AIDSLINE
       MED/95146776
 AB    Serum specimens (n = 161) from 31 persons before and after human
       immunodeficiency virus type 1 (HIV-1) seroconversion were tested for
       anti-CD4 antibodies. These antibodies were detected by both ELISA and
       Western blot in 55% (17/31) of subjects when HIV-1 seroconversion was
       detected and in 26% (8/31) from sera obtained 6-24 months earlier. A
       decrease in CD4+ cell number was associated more with development of
       anti-CD4 antibodies or peak anti-CD4 antibody activity than with
       development of anti-HIV-1 antibodies. Quantitative DNA polymerase chain
       reaction assay of peripheral blood mononuclear cells from 7
       seroconverters showed evidence of HIV-1 infection in 4 of 4 specimens
       obtained after HIV-1 seroconversion but was nonreactive for 12 of 12
       specimens obtained before HIV-1 seroconversion, including 4 specimens
       positive for anti-CD4 antibodies by ELISA and Western blot. Therefore,
       anti-CD4 antibodies are frequently present in the sera of HIV-1-infected
       persons before and at the time HIV-1 seroconversion is detectable and
       are associated with a decline in CD4+ cell counts, but they are not a
       marker for HIV-1 infection in seronegative persons.
 DE    Antibodies/*BLOOD  Antigens, CD4/*IMMUNOLOGY  Blotting, Western
       Comparative Study  CD4 Lymphocyte Count  CD4-CD8 Ratio  CD4-Positive
       T-Lymphocytes/*IMMUNOLOGY  DNA, Viral/*BLOOD  Enzyme-Linked
       Immunosorbent Assay  Human  HIV Seronegativity/IMMUNOLOGY  HIV
       Seropositivity/*IMMUNOLOGY  HIV-1/*IMMUNOLOGY  Polymerase Chain Reaction
       Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  Time Factors
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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