Document 0373
 DOCN  M9550373
 TI    Inactivation of human immunodeficiency virus type 1 by alcohols.
 DT    9505
 AU    van Bueren J; Larkin DP; Simpson RA; Laboratory of Hospital Infection,
       Central Public Health; Laboratory, London, UK.
 SO    J Hosp Infect. 1994 Oct;28(2):137-48. Unique Identifier : AIDSLINE
       MED/95146756
 AB    Alcohols are commonly used as disinfectants for skin, surfaces and
       immersion of some medical instruments. Measurements of the activity of
       alcohols against human immunodeficiency virus type 1 (HIV-1) must take
       account of the compatibility of neutralizers used to stop the
       disinfectant reaction, and of toxicity to the cell line used to detect
       residual virus. We have developed protocols to measure the efficacy of
       alcohols against HIV in suspension and dried onto surfaces in the
       presence of high and low protein concentrations. High titres of HIV in
       suspension were rapidly inactivated by 70% ethanol, independent of the
       protein load. When virus was dried onto a glass surface, the rate of
       inactivation decreased when high levels of protein were present. Due to
       its rapid evaporation, a spray or a wipe with alcohol cannot be
       guaranteed to disinfect a surface contaminated with blood or other body
       fluids without preliminary cleaning.
 DE    Alcohol, Ethyl/*PHARMACOLOGY  Alcohol, Propyl/*PHARMACOLOGY  Comparative
       Study  Disinfectants/*PHARMACOLOGY  Disinfection/METHODS  Human
       HIV-1/*DRUG EFFECTS  Microbiological Techniques  Support, Non-U.S. Gov't
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).