Document 0386
 DOCN  M9550386
 TI    Neuroleptic malignant syndrome in an AIDS patient: clinical and
       pathological findings.
 DT    9505
 AU    Gabellini AS; Pezzoli A; De Massis P; Casadei G; Grillo A; Sacquegna T;
       Servizio di Neurologia, Ospedale Maggiore, Bologna.
 SO    Ital J Neurol Sci. 1994 Sep;15(6):293-5. Unique Identifier : AIDSLINE
       MED/95146316
 AB    Neuroleptic malignant syndrome (NMS) has been recently described
       following therapy with non strictly neuroleptic drugs that alter
       dopaminergic function, such as sulpiride and metoclopramide, and might
       occur more easily in patients with functional or organic brain
       disorders. We observed an AIDS patient who suffered from NMS following
       treatment with clotiapine for insomnia and agitation. Two months later,
       he presented with a similar syndrome following antiemetic treatment with
       alizapride. On both occasions, the symptoms completely regressed after
       the administration of dopaminergic and muscle relaxant drugs. The
       patient died of pneumonia one month after the last episode. The present
       paper describes the clinical and pathological findings.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS/PATHOLOGY  Adult
       Antiemetics/ADVERSE EFFECTS  Antipsychotic Agents/ADVERSE EFFECTS  Case
       Report  Dibenzothiazepines/ADVERSE EFFECTS  Dopamine Agents/THERAPEUTIC
       USE  Heroin Dependence/COMPLICATIONS  Human  Male  Muscle Relaxants,
       Central/THERAPEUTIC USE  Neuroleptic Malignant
       Syndrome/*COMPLICATIONS/DRUG THERAPY/  PATHOLOGY  Pyrrolidines/ADVERSE
       EFFECTS  Substantia Nigra/PATHOLOGY  JOURNAL ARTICLE

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