Document 0387
 DOCN  M9550387
 TI    Effects of a traditional Chinese herbal medicine, Kanzo-bushi-to, on the
       resistance of thermally injured mice infected with herpes simplex virus
       type 1.
 DT    9505
 AU    Matsuo R; Ball MA; Kobayashi M; Herndon DN; Pollard RB; Suzuki F;
       Department of Internal Medicine, University of Texas Medical; Branch,
       Galveston 77555-0882.
 SO    Int J Immunopharmacol. 1994 Oct;16(10):855-63. Unique Identifier :
       AIDSLINE MED/95146223
 AB    The protective effect of Kanzo-bushi-to (TJS-038) was investigated on
       the opportunistic infection of herpes simplex virus type 1 (HSV) in
       thermally injured mice (TI-Mice). We have previously reported that
       TI-Mice were approximately 100 times more susceptible to HSV infection
       than normal mice (N-Mice) and that CD8+ suppressor T (ST)-cells induced
       by burn injury were involved in causing this increased susceptibility of
       TI-Mice. Increased susceptibility of TI-Mice to the infection was
       reversed to the levels observed in N-Mice when TI-Mice were treated
       intraperitoneally with TJS-038 at a dose of 5 mg/kg 1 and 4 days after
       thermal injury. The activity of ST-cells was greatly decreased in
       TI-Mice treated with TJS-038. The generation of Vicia villosa
       lectin-adherent CD4+ CD28+ TCR-alpha/beta+ contrasuppressor T
       (Contra-ST)-cells associated with the appearance of ST-cells was
       expanded and occurred earlier in spleens of TJS-038-treated TI-Mice as
       compared with that of untreated TI-Mice. The improved resistance of
       TJS-038-treated TI-Mice to the infection was transferred to untreated
       TI-Mice by adoptive transfer of Contra-ST-cells prepared from
       TJS-038-treated TI-Mice. These results suggest that TJS-038 may restore
       the resistance of TI-Mice to the HSV infection through the expanded
       generation of Contra-ST-cells.
 DE    Animal  Burns/COMPLICATIONS/*DRUG THERAPY  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY  CD8-Positive T-Lymphocytes/DRUG
       EFFECTS/IMMUNOLOGY  Drugs, Chinese Herbal/PHARMACOLOGY/*THERAPEUTIC USE
       Herpes Simplex/*IMMUNOLOGY  Immunity, Natural/DRUG EFFECTS
       Immunotherapy, Adoptive  Male  Mice  Mice, Inbred BALB C  JOURNAL
       ARTICLE

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