Document 0391
 DOCN  M9550391
 TI    Parvovirus B19 infection in HIV-1 infected patients with anemia.
 DT    9505
 AU    Gyllensten K; Sonnerborg A; Jorup-Ronstrom C; Halvarsson M; Yun Z; Dept.
       of Infectious Diseases, Huddinge Hospital, Sweden.
 SO    Infection. 1994 Sep-Oct;22(5):356-8. Unique Identifier : AIDSLINE
       MED/95146180
 AB    Serum samples were analysed for IgM and IgG antibodies to parvovirus by
       ELISA and for parvovirus B19 DNA by polymerase chain reaction (PCR) in
       69 HIV-1 infected Swedish patients with anemia and in 37 HIV-1 infected
       subjects without anemia. In 5/69 anemic patients, parvovirus B19 DNA was
       detected despite the lack of IgM antibody activity to the virus. The
       detection of parvovirus B19 DNA was significantly correlated to the
       degree of anemia in the anemic patients. In two patients who had a
       chronic anemia, a persistent parvovirus infection was detected by PCR,
       but not by serology, for 1 and 1.5 years, respectively. The results
       suggest that persistent parvovirus infection is a rare cause of anemia,
       but important to identify, since the infection is potentially treatable
       with intravenous immunoglobulin.
 DE    Anemia/BLOOD/*COMPLICATIONS  AIDS-Related Opportunistic
       Infections/*BLOOD  Base Sequence  Case-Control Studies  Chronic Disease
       DNA, Viral/BLOOD  Erythema Infectiosum/BLOOD/*VIROLOGY  Human  *HIV-1
       Molecular Sequence Data  *Parvovirus B19, Human  Prevalence
       Retrospective Studies  JOURNAL ARTICLE

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