Document 0400
 DOCN  M9550400
 TI    Evidence for intact costimulation via CD28 and CD27 molecules in
       hyporesponsive T cells from human immunodeficiency virus-infected
       individuals.
 DT    9505
 AU    Meyaard L; Kuiper H; Otto SA; Wolthers KC; van Lier RA; Miedema F;
       Department of Clinical Viro-Immunology, Central Laboratory of The;
       Netherlands Red Cross Blood Transfusion Service, Amsterdam.
 SO    Eur J Immunol. 1995 Jan;25(1):232-7. Unique Identifier : AIDSLINE
       MED/95145532
 AB    In the activation of T cells, the primary signal is antigen-specific and
       given through T cell receptor (TcR)/CD3 ligation. Furthermore,
       costimulatory molecules such as CD28 and CD27, provide an essential
       signal for activation through interaction with their ligands, present on
       the membrane of antigen-presenting cells. During asymptomatic human
       immunodeficiency virus (HIV)-1 infection, T cell function is
       progressively lost. Here, we investigated whether in the presence of
       impaired responses of T cells from HIV-infected individuals to signal
       one, costimulation through CD28 and CD27 after interaction with their
       natural ligands CD80 and CD70 is intact. T cell proliferative responses
       to signal one in combination with CD80 or CD70 were decreased in a large
       fraction of asymptomatically HIV-infected individuals. This was due to
       impaired responses of signal one but not to impaired responses to
       costimulation, since CD80 or CD70 did enhance signal one-mediated
       proliferative responses to a normal extent. Moreover, in individuals
       with proliferative responses to signal one that were decreased to 50% of
       normal T cell responses, costimulation even was increased compared to
       controls. Our results demonstrate that in HIV-infected individuals the
       response to costimulation is relatively preserved compared to responses
       to the first signal and point to the defect in T cells in HIV infection
       being primarily in the CD3/TcR-mediated pathway.
 DE    Antigens, CD/*IMMUNOLOGY  Antigens, CD2/IMMUNOLOGY  Antigens,
       CD27/IMMUNOLOGY  Antigens, CD28/IMMUNOLOGY  Antigens, CD3/IMMUNOLOGY
       B-Cell Activation Antigen/IMMUNOLOGY  Human  HIV Infections/*IMMUNOLOGY
       Lymphocyte Transformation/*IMMUNOLOGY  Male  Membrane
       Proteins/IMMUNOLOGY  Receptors, Antigen, T-Cell/IMMUNOLOGY  Signal
       Transduction/IMMUNOLOGY  Support, Non-U.S. Gov't
       T-Lymphocytes/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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