Document 0407
 DOCN  M9550407
 TI    Relationship between fluconazole sensitivity of Candida albicans
       isolates from HIV positive patients and serotype, adherence and CD4+
       lymphocyte count.
 DT    9505
 AU    Imbert-Bernard C; Valentin A; Reynes J; Mallie M; Bastide JM;
       Laboratoire de Parasitologie-Immunologie, Faculte de Pharmacie,;
       Montpellier, France.
 SO    Eur J Clin Microbiol Infect Dis. 1994 Sep;13(9):711-6. Unique Identifier
       : AIDSLINE MED/95145465
 AB    The sensitivity of fluconazole, serotype and adherence to buccal
       epithelial cells of 46 Candida albicans isolates was studied in vitro.
       Strains were isolated from 18 HIV-positive patients with variable CD4+
       lymphocyte counts who were receiving long-term fluconazole therapy.
       Results showed that sensitivity to fluconazole correlated with serotype.
       Of the sensitive isolates 81.5% were serotype A and 18.5% serotype B,
       whereas of the resistant isolates 37.5% were serotype A and 62.5%
       serotype B. Sensitivity to fluconazole also correlated with adherence
       capacity, resistant isolates showing slightly less adherence to buccal
       epithelial cells than sensitive isolates. Weakly adherent isolates
       represented 87% of resistant isolates and only 63% of sensitive
       isolates. Resistant strains were isolated in highly immunocompromised
       patients. All strains isolated in patients with CD4+ lymphocyte counts
       above 200 lymphocytes/microliters were sensitive, whereas intermediate
       and resistant strains were isolated in patients with counts below 200
       lymphocytes/microliters. Statistical analyses showed no correlation
       between adherence of isolates to buccal epithelial cells and CD4+
       lymphocyte counts.
 DE    AIDS-Related Opportunistic Infections/*DRUG THERAPY/IMMUNOLOGY  Candida
       albicans/CLASSIFICATION/*DRUG EFFECTS/PHYSIOLOGY  Candidiasis,
       Oral/*DRUG THERAPY/IMMUNOLOGY  Confidence Intervals  CD4 Lymphocyte
       Count  Fluconazole/*PHARMACOLOGY/THERAPEUTIC USE  Human  HIV
       Seropositivity/IMMUNOLOGY/MICROBIOLOGY  *HIV-1  Microbial Sensitivity
       Tests  Mouth Mucosa/*MICROBIOLOGY  Serotyping  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).