Document 0409
 DOCN  M9550409
 TI    [An immunohistochemical study of cornea and adjacent bulbar conjunctiva
       in Mooren's ulcer]
 DT    9505
 AU    Wang Z; Chen JQ; Zheng HL; Zhongshan Ophthalmic Center, Sun Yat-sen
       University of Medical; Sciences, Guangzhou.
 SO    Chung Hua Yen Ko Tsa Chih. 1994 May;30(3):218-20. Unique Identifier :
       AIDSLINE MED/95145292
 AB    The specimens of the corneal lesions and their adjacent bulbar
       conjunctivas taken from 14 cases with Mooren's ulcers were studied by
       immunohistochemical techniques to investigate the expression of HLA-DR
       antigen and the subgroups of lymphocytes. It is discovered that there is
       an aberrant expression of HLA-DR antigen in a large amount of
       keratoconjunctival epithelial cells and stromal keratocytes and
       simultaneously, the CD4/CD8 ratio is significantly higher than that of
       the normal control group. The results suggest that the aberrant
       expression of MHC-II antigen in the resident cells at the peripheral
       cornea and its adjacent conjunctiva and a raised local TH/TS ratio
       leading to an excessive autoimmune reactivity be possibly the direct
       cause of the pathogenesis of the Mooren's ulcer.
 DE    Adult  Conjunctiva/*IMMUNOLOGY  Cornea/*IMMUNOLOGY  Corneal
       Ulcer/*IMMUNOLOGY  CD4-CD8 Ratio  English Abstract  Female  Human
       HLA-DR Antigens/METABOLISM  Immunohistochemistry  Male  Middle Age
       T-Lymphocyte Subsets  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).