Document 0418
 DOCN  M9550418
 TI    [Acute allograft glomerulopathy and its etiology]
 DT    9505
 AU    Liao LM; Shi BY; Li SL; Department of Urology, Beijing 309th Hospital.
 SO    Chung Hua I Hsueh Tsa Chih. 1994 Oct;74(10):615-7, 647. Unique
       Identifier : AIDSLINE MED/95144592
 AB    Acute allograft glomerulopathy (AAG) is a distinctive glomerular lesion
       of renal allografts. Its clinical signs and symptoms, pathology and
       etiology were studied. The frequency of AAG was 57.6% in renal
       transplant recipients. The clinical signs and symptoms included urinary
       protein, cast, WBC and RBC, etc. The pathologic features were diffuse
       endothelial hypertrophy and necrosis accompanied by accumulation of
       periodic acid-schiff (PAS) positive material and mononuclear cells that
       resulted in obliteration of glomerular capillaries, basilar membrane
       proliferation and immune complexes deposition. To elucidate the
       pathogenesis of AAG, we diagnosed HCMV infection of renal
       transplantation recipients by using polymerase chain reaction (PCR) and
       ELISA. Circulating T cell subsets were detected with APAAP method. OR of
       AAG occurrence in HCMV infection group was 32.4 times as high as in
       non-HCMV infection one (P < 0.01). OR of AAG occurrence in CD4/CD8 < 1.5
       group was 12 times as high as in CD4/CD8 > 1.5 one (P < 0.01); so AAG
       was strongly associated with HCMV infection and T cell subsets changes
       (decreased or inverted CD4/CD8 ratio) induced by HCMV.
 DE    Adult  *Cytomegalovirus Infections  CD4-CD8 Ratio  English Abstract
       Female  Glomerulonephritis/IMMUNOLOGY/*VIROLOGY  Human  *Kidney
       Transplantation  Male  Middle Age  Postoperative
       Complications/IMMUNOLOGY/*VIROLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).