Document 0421
 DOCN  M9550421
 TI    The enteric nervous and immune systems: interactions for mucosal
       immunity and inflammation.
 DT    9505
 AU    Pascual DW; Kiyono H; McGhee JR; Department of Oral Biology, University
       of Alabama, Birmingham; Medical Center 35294.
 SO    Immunomethods. 1994 Aug;5(1):56-72. Unique Identifier : AIDSLINE
       MED/95144463
 AB    A number of anatomical studies have demonstrated the presence of
       peptidergic nerve fibers infiltrating mucosal lymphoid tissues. The
       exact mechanisms of how neuropeptides are released to affect these
       lymphoid sites are unclear, but radiolabeled binding studies have shown
       that mucosal leukocytes bear a number of neuropeptide receptors on their
       cell surfaces capable of responding to neural signals. The presence of
       neuropeptide-containing fibers and the ability to receive neural signals
       suggest that mucosal lymphocytes can be influenced by neurogenic
       mediators. The objectives set forth in this review are to provide what
       is currently known about the ability of substance P and vasoactive
       intestinal peptide to promote mucosal IgA responses in the
       gastrointestinal tract via Th2 mechanisms and to discuss how these
       neuropeptides contribute to the exacerbation of the inflammatory
       diseases of the gastrointestinal tract. We describe how immune responses
       develop in the gastrointestinal immune system and emphasize how
       neuropeptides may influence the differentiation of lymphocytes in
       mucosal inductive tissues and their subsequent expression in mucosal
       effector sites. Finally, we discuss new techniques developed by the
       Mucosal Immunization Research Group that have enabled the study of
       mucosal immune responses.
 DE    Animal  Enteric Nervous System/*PHYSIOLOGY  Human
       IgA/*BIOSYNTHESIS/IMMUNOLOGY  Immunologic Memory  Inflammation
       Inflammatory Bowel Diseases/IMMUNOLOGY/PATHOLOGY  Intestinal
       Mucosa/*IMMUNOLOGY/INNERVATION  Mice  Neuroimmunomodulation
       Neuropeptides/*PHYSIOLOGY  Peyer's Patches/IMMUNOLOGY/*INNERVATION  Rats
       Receptors, Neuropeptide/DRUG EFFECTS/PHYSIOLOGY  Substance P/PHYSIOLOGY
       Support, U.S. Gov't, P.H.S.  Th2 Cells/*IMMUNOLOGY  Vasoactive
       Intestinal Peptide/PHYSIOLOGY  JOURNAL ARTICLE  REVIEW  REVIEW, ACADEMIC

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