Document 0427
 DOCN  M9550427
 TI    Studies on thermophile products. IX. Isofatty acid-containing
       phosphatidylglycerol that enhances the induction of concanavalin
       A-activated suppressor T cells.
 DT    9505
 AU    Kohama Y; Semba T; Tanaka K; Tone H; Tanaka S; Itoh S; Mimura T; Faculty
       of Pharmaceutical Sciences, Osaka University, Japan.
 SO    Biol Pharm Bull. 1994 Sep;17(9):1171-5. Unique Identifier : AIDSLINE
       MED/95144089
 AB    A new enhancer of the induction of concanavalin A (Con A)-activated
       suppressor T (Ts) cells has been demonstrated in the ethanolysate of
       Bacillus stearothermophilus UBT8038. It was purified by successive
       silica gel column chromatographies and identified as
       phosphatidylglycerol with C14:0-C18:0 isofatty acids (Fr. 7-C). Mouse
       splenocytes activated with Con A and Fr. 7-C (0.01-1 microgram/ml) in
       vitro significantly suppressed the proliferative response of syngenic
       splenocytes by mitogen stimulation in a dose-dependent manner, compared
       to those stimulated by Con A alone. The immunosuppressive response
       enhanced by Fr. 7-C disappeared when the cell populations of Thy-1.2 or
       CD8 positive lymphocytes were depleted. The result strongly suggests
       that Fr. 7-C is an immunosuppressive substance which enhances the
       induction of Con A-activated CD8 positive Ts cells.
 DE    Animal  Bacillus stearothermophilus/CHEMISTRY  Chromatography, Thin
       Layer  Concanavalin A/*PHARMACOLOGY  Cytotoxicity Tests, Immunologic
       CD8-Positive T-Lymphocytes/DRUG EFFECTS  Fatty Acids/ISOLATION &
       PURIF/*PHARMACOLOGY  Lymphocyte Transformation/*DRUG EFFECTS  Male  Mice
       Mice, Inbred BALB C  Phosphatidylglycerols/ISOLATION &
       PURIF/*PHARMACOLOGY  Spleen/CYTOLOGY/DRUG EFFECTS  T-Lymphocytes,
       Suppressor-Effector/*DRUG EFFECTS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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