Document 0429
 DOCN  M9550429
 TI    Clinical features of HIV infection in drug users of Manipur.
 DT    9505
 AU    Panda S; Kamei G; Pamei M; Sarkar S; Sarkar K; Singh ND; Deb BC; Indian
       Council of Medical Research Unit for Research on AIDS,; North Eastern
       States of India, Salt Lake City, Calcutta, West; Bengal.
 SO    Natl Med J India. 1994 Nov-Dec;7(6):267-9. Unique Identifier : AIDSLINE
       MED/95144029
 AB    BACKGROUND. The human immunodeficiency virus was first detected in young
       intravenous drug users in Manipur in 1989 and it quickly reached a high
       prevalence in this group. Diagnostic facilities are scarce and it is
       thus important to suspect the presence of the infection by its clinical
       features. METHODS. We did a cross-sectional survey for 13 months among
       residents of different detoxification centres of Imphal, Manipur, to
       study the sensitivity, specificity and positive predictive values of
       different signs and symptoms occurring at the early phase of the
       infection. RESULTS. Most of the young injectors in this survey were
       found to be in the early phases (stage I 43%; stage II 32%; stage III
       15% and stage IV 9.9%) of the World Health Organization clinical staging
       of human immunodeficiency virus infection and disease. Herpes zoster,
       oral candidiasis, pruritic papular eruptions, jaundice and
       lymphadenopathy had positive predictive values of 100%, 100%, 93%, 93%
       and 88% respectively. Cryptosporidial diarrhoea and tuberculosis
       (pulmonary and extrapulmonary) were also encountered. CONCLUSION.
       Intravenous drug users in Manipur who have human immunodeficiency virus
       infection suffer from different opportunistic infections which give rise
       to clinical features that are easily recognizable. It is important to be
       aware of these in areas which lack diagnostic facilities for confirming
       the infection.
 DE    Adult  AIDS-Related Opportunistic Infections  Cross-Sectional Studies
       Human  HIV Infections/EPIDEMIOLOGY/*PHYSIOPATHOLOGY  HIV
       Seropositivity/EPIDEMIOLOGY  India/EPIDEMIOLOGY  Sensitivity and
       Specificity  Substance Abuse, Intravenous/EPIDEMIOLOGY/*VIROLOGY
       Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).