Document 0434
 DOCN  M9550434
 TI    [New diagnostic developments in infection serology]
 DT    9505
 AU    Sibrowski W; Brauer P; Institut fur Transfusionsmedizin, Westfalischen;
       Wilhelms-Universitat, Munster.
 SO    Infusionsther Transfusionsmed. 1994 Nov;21 Suppl 3:19-22. Unique
       Identifier : AIDSLINE MED/95143922
 AB    New developments concerning the diagnostic of virus-transmitted diseases
       led to a strong improvement of virus security in hemotherapy. The
       introduction of additional virus antigens associated with the core
       region of the hepatitis C virus (HCV) resulted in an increase of
       sensitivity and especially of specificity of second-generation enzyme
       immuno assays (EIAs). The recombinant immunoblot (RIBA) with 4 synthetic
       antigens continues to be the most accepted confirmatory test in the
       field of HCV diagnostic. Beside the simultaneous detection of specific
       IgG and IgM, especially the HIV-p24 antigen test is discussed concerning
       HIV-1, -2 diagnostic in order to shorten the 'windows period' in the
       early time of infection. It is assumed that the HIV-p24 antigen test is
       not able to effectively improve virus security in areas with low HIV-1,
       -2 prevalence.
 DE    AIDS Serodiagnosis/METHODS  *Blood-Borne Pathogens  English Abstract
       Hepatitis Antibodies/BLOOD  Hepatitis C/IMMUNOLOGY/PREVENTION &
       CONTROL/TRANSMISSION  Human  HIV Antibodies/BLOOD  HIV Antigens/BLOOD
       HIV-1/IMMUNOLOGY  HIV-2/IMMUNOLOGY  Serodiagnosis/*METHODS  Virus
       Diseases/IMMUNOLOGY/*PREVENTION & CONTROL/TRANSMISSION  JOURNAL ARTICLE
       REVIEW  REVIEW, TUTORIAL

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