Document 0435
 DOCN  M9550435
 TI    [Effects of Tripterygiitotorum in the treatment of insulin dependent
       diabetes mellitus with islet transplantation]
 DT    9505
 AU    Zhang XZ; Li S; Wu XZ; Division of Endocrinology, Ganquan Hospital,
       Shanghai Railway; Medical College.
 SO    Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1994 Aug;14(8):451-3. Unique
       Identifier : AIDSLINE MED/95143895
 AB    The therapeutical efficacy of islet transplantation in treating
       insulin-dependent diabetes mellitus (IDDM) patients is marked for a
       short time and the long-term efficacy is unsatisfactory. So 30 IDDM
       patients given tripterygiitotorum (T II) were compared with 24 IDDM
       patients without using any immunosuppressive agents after islet
       transplantation. Results: prior to transplantation both the numbers of T
       lymphocyte subpopulations such as CD2, CD4, CD8 and the concentrations
       of C-peptide in all IDDM patients were lowered; after transplantation
       the numbers of CD2, CD4 were significantly elevated (P < 0.01), the
       ratio of CD4/CD8 in control group was higher than that in TII group (P <
       0.01), while the concentration of C-peptide were greatly increased
       (normal: 2.24 +/- 0.34; before transplantation: 0.21 +/- 0.01; 15 days
       after transplantation: 3.24 +/- 1.2 ng/ml). The peak value of C-peptide
       in TII group began decreasing half a year after transplantation and it
       gradually dropped to the baseline level. The dose of insulin all were
       significantly reduced, and 3 patients stopped altogether. Half a year
       after transplantation TII group remained stable for the requirement of
       insulin, whereas the control group gradually increased the dose of
       insulin. (1) Islet transplantation could adjust the immunological
       disorder in IDDM patients, increase the numbers of T lymphocyte subset
       such as CD2, CD4, CD8 while the chronic immuno-rejective response
       occurred. (2) T II inhibited both the numbers and function of T
       lymphocyte subpopulation and normalized the ratio of CD4/CD8. (3) TII
       prolonged the survival time of grafts in IDDM patients and suppressed
       immunological rejection.(ABSTRACT TRUNCATED AT 250 WORDS)
 DE    Adolescence  Adult  C-Peptide/BLOOD  CD4-CD8 Ratio/DRUG EFFECTS
       Diabetes Mellitus, Insulin-Dependent/*DRUG THERAPY/SURGERY  Drugs,
       Chinese Herbal/*THERAPEUTIC USE  English Abstract  Female  Fetal Tissue
       Transplantation  Human  Immunosuppressive Agents/*THERAPEUTIC USE
       *Islets of Langerhans Transplantation  Male  Saponins/THERAPEUTIC USE
       T-Lymphocyte Subsets/DRUG EFFECTS/IMMUNOLOGY  CLINICAL TRIAL  JOURNAL
       ARTICLE  RANDOMIZED CONTROLLED TRIAL

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