Document 0436
 DOCN  M9550436
 TI    Cerebrospinal fluid analysis in HIV-1-infected children: immunological
       and virological findings before and after AZT therapy.
 DT    9505
 AU    Laverda AM; Gallo P; De Rossi A; Sivieri S; Cogo P; Pagliaro A;
       Chieco-Bianchi L; Tavolato B; Department of Paediatrics, University of
       Padua School of; Medicine, Padova, Italy.
 SO    Acta Paediatr. 1994 Oct;83(10):1038-42. Unique Identifier : AIDSLINE
       MED/95143843
 AB    Immunological and viral studies were conducted on cerebrospinal fluid
       from 31 HIV-1-infected children, of whom 23 were neurologically
       asymptomatic and 8 had progressive encephalopathy. After AZT treatment,
       a second cerebrospinal fluid specimen was obtained from 15 children, 11
       of whom were neurologically asymptomatic and 4 had progressive
       encephalopathy. Virus isolation and p24Ag detection were more frequent
       in children with progressive encephalopathy than in asymptomatic
       children (66% versus 12%) and were inversely correlated with intrathecal
       HIV-1-antibody detection (anti-gag AB: 25% versus 70%). High
       concentrations of interleukin-1 beta (IL-1 beta) and IL-6 were found in
       children with progressive encephalopathy (50% and 37%, respectively),
       but low levels were also detected in some asymptomatic children (13% and
       9%, respectively). Tumour necrosis factor-alpha (TNF alpha) was not
       found. AZT treatment induced disappearance of p24Ag in cerebrospinal
       fluid, as well as a marked reduction in cytokine levels. Cytokine
       determination may be useful in monitoring AZT treatment in children with
       progressive encephalopathy.
 DE    Antibodies, Viral/ANALYSIS  AIDS Dementia Complex/CEREBROSPINAL
       FLUID/DRUG THERAPY/IMMUNOLOGY  Child  Child, Preschool  Female  Human
       HIV Infections/*CEREBROSPINAL FLUID/DRUG THERAPY/IMMUNOLOGY
       *HIV-1/IMMUNOLOGY  Infant  Interleukin-1/CEREBROSPINAL FLUID
       Interleukin-6/CEREBROSPINAL FLUID  Male  Support, Non-U.S. Gov't  Tumor
       Necrosis Factor/CEREBROSPINAL FLUID  Zidovudine/*THERAPEUTIC USE
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).