Document 0438
 DOCN  M9550438
 TI    Growth impairment, IGF I hyposecretion and thyroid dysfunction in
       children with perinatal HIV-1 infection.
 DT    9505
 AU    Matarazzo P; Palomba E; Lala R; Ciuti E; Altare F; de Sanctis L; Tovo
       PA; Department of Paediatric Endocrinology, Regina Margherita;
       Children's Hospital, Turin, Italy.
 SO    Acta Paediatr. 1994 Oct;83(10):1029-34. Unique Identifier : AIDSLINE
       MED/95143841
 AB    We evaluated the growth pattern, bone age, insulin-like growth factor I
       (IGF I) secretion and thyroid function in 24 perinatally infected
       children: 9 asymptomatic or paucisymptomatic (group 1) and 15 with a
       more advanced disease state and treated with zidovudine (group 2).
       Statural and ponderal growth were compared with those of 37 at-risk
       children who seroreverted. During the two-year follow-up, 22% of
       children in group 1 had impaired growth, 33% bone age delay, 45% reduced
       IGF I levels but none had thyroid dysfunction. In group 2, 53% had
       growth failure, 53% bone age delay, 86% reduced IGF I levels and 40%
       thyroid dysfunction. Among seroreverters, none showed growth impairment;
       statistically significant differences were found for height, weight and
       height velocity between perinatally infected children and seroreverters.
       Since auxological and hormonal evaluations run parallel to the clinical
       course of infection, these indices may be useful in monitoring disease
       progression.
 DE    Age Determination by Skeleton  Child  Child, Preschool  Disease
       Progression  Female  Growth Disorders/MICROBIOLOGY/*PHYSIOPATHOLOGY
       Human  HIV Infections/CONGENITAL/COMPLICATIONS/*PHYSIOPATHOLOGY  HIV
       Seropositivity/PHYSIOPATHOLOGY  *HIV-1/IMMUNOLOGY  Infant  Infant,
       Newborn  Insulin-Like Growth Factor I/*SECRETION  Male  Support,
       Non-U.S. Gov't  Thyroid Gland/*PHYSIOPATHOLOGY  JOURNAL ARTICLE

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