Document 0459
 DOCN  M9550459
 TI    Head and neck lymphomas associated with human immunodeficiency virus
       infection.
 DT    9505
 AU    Carbone A; Vaccher E; Barzan L; Gloghini A; Volpe R; De Re V; Boiocchi
       M; Monfardini S; Tirelli U; Division of Pathology, Istituto Nazionale di
       Ricovero e Cura a; Carattere Scientifico, Aviano.
 SO    Arch Otolaryngol Head Neck Surg. 1995 Feb;121(2):210-8. Unique
       Identifier : AIDSLINE MED/95142968
 AB    OBJECTIVE: To focus on clinicopathologic data of non-Hodgkin's lymphomas
       (NHLs) of the head and neck area (with lymph nodal or extranodal
       localization) arising in patients with immunodeficiency virus (HIV)
       infection. PATIENTS: Among 73 evaluable patients for presenting
       symptoms, of a total of 82 with HIV-related NHLs whose conditions were
       diagnosed at the Centro di Riferimento Oncologico, Aviano (Italy),
       between September 1984 and May 1992, 15 (21%) had primary, solitary head
       and neck (P-HN) lymphoma and 13 (18%) had systemic head and neck (S-HN)
       lymphoma arising from this region. RESULTS: Ten (67%) of 15 patients
       with P-HN NHL had stages I and II, whereas all patients with S-HN NHL
       had stages III and IV. Twenty-seven of 28 patients had extranodal
       disease at presentation, the principal sites being Waldeyer's ring and
       soft tissues. There were only high-grade (14 cases) or
       intermediate-grade (three cases) NHLs, the most frequent histotypes
       being small noncleaved cell, Burkitt's type, and large-cell
       immunoblastic. Seven of 11 cases in the miscellaneous group of the
       working formulation were classified as Ki-1+ anaplastic large-cell
       lymphoma. By immunophenotypic and genotypic characterization, a B-cell
       derivation was suggested for 21 of 28 NHLs. After combination
       chemotherapy with or without radiotherapy, a complete remission was
       observed in seven (58%) of 12 patients with P-HN lymphoma and in only
       two patients with S-HN lymphoma. Median survival was 9.8 months for the
       patients with P-HN lymphoma and 8.3 months for the other patients.
       Thirteen patients died, the most common causes of death being
       opportunistic infections (five cases) and progression of lymphoma (four
       cases). CONCLUSIONS: Most HIV-infected patients with head and neck NHL
       had severe immunodeficiency, extranodal disease, aggressive histologic
       findings, and a poor treatment response.
 DE    Adult  Female  Head and Neck Neoplasms/MORTALITY/*PATHOLOGY/THERAPY
       Human  Lymphoma, AIDS-Related/MORTALITY/*PATHOLOGY/THERAPY  Lymphoma,
       Non-Hodgkin's/MORTALITY/*PATHOLOGY/THERAPY  Male  Middle Age
       Retrospective Studies  Support, Non-U.S. Gov't  Survival Rate  JOURNAL
       ARTICLE

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       protected by Copyright Law (Title 17, U.S.Code).