Document 0681
 DOCN  M9550681
 TI    Cytokine receptor alterations during HIV infection in the human central
       nervous system.
 DT    9505
 AU    Masliah E; Ge N; Achim CL; Wiley CA; University of California, San
       Diego, Department of Neurosciences,; La Jolla 92093-0624.
 SO    Brain Res. 1994 Nov 7;663(1):1-6. Unique Identifier : AIDSLINE
       MED/95153314
 AB    Cytokines are potent factors mediating interactions between the immune
       and nervous systems. Cytokines released by macrophages/microglia, the
       predominant immune cell within the brain, have been proposed to modulate
       neuronal survival and death. In human immunodeficiency
       virus-encephalitis (HIVE), cytokines could modulate neurologic damage if
       nervous system cells possessed appropriate receptors. We hypothesized
       that the populations of neurons vulnerable to the toxic effects of
       cytokines in HIVE might contain specific receptors for these molecules.
       We examined the distribution of cytokine receptors in the human brain
       utilizing fluorescent-labeled cytokines combined with confocal laser
       microscopy imaging. Phycoerythrin-conjugated interleukin-1 beta and
       phycoerythrin-Avidin/biotin conjugated transforming growth factor beta 1
       labeled dendritic processes of neurons in the neocortex. Labeling was
       abolished by pre-incubation with unlabeled cytokines. In cases with
       moderate HIVE, an average 35% increase in intensity of labeling was
       observed compared to cases without HIVE or with cases with severe HIVE.
       The patterns of interleukin 2 labeling were not altered in HIVE. These
       results suggest that neurons susceptible to cytokine-mediated damage
       during the progression of HIVE display abnormal patterns of cytokine
       receptor labeling.
 DE    Adult  Analysis of Variance  Autopsy  AIDS Dementia
       Complex/*IMMUNOLOGY/PATHOLOGY  Brain/*IMMUNOLOGY/PATHOLOGY  Cells,
       Cultured  Comparative Study  Frontal Lobe/IMMUNOLOGY  Human  HIV
       Infections/IMMUNOLOGY/PATHOLOGY  Interleukin-1/METABOLISM
       Macrophages/*IMMUNOLOGY  Monocytes/IMMUNOLOGY
       Neurons/*IMMUNOLOGY/PATHOLOGY  Receptors, Cytokine/*METABOLISM
       Reference Values  Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.
       Transforming Growth Factor beta/METABOLISM  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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