Document 0796
 DOCN  M9550796
 TI    Proton MR spectroscopy of brain abnormalities in neonates born to
       HIV-positive mothers.
 DT    9505
 AU    Cortey A; Jarvik JG; Lenkinski RE; Grossman RI; Frank I;
       Delivoria-Papadopoulos M; Department of Physiology, University of
       Pennsylvania School of; Medicine, Philadelphia.
 SO    AJNR Am J Neuroradiol. 1994 Nov;15(10):1853-9. Unique Identifier :
       AIDSLINE MED/95168128
 AB    PURPOSE: To examine the sensitivity of proton MR spectroscopy for
       detecting early central nervous system abnormalities in neonates born to
       human immunodeficiency virus (HIV)-positive mothers. METHODS: Asleep,
       unsedated, and continuously monitored by electrocardiography, 10
       newborns, 5 with HIV-positive and 5 with HIV-negative mothers, were
       studied within the first 10 days of life in a 1.5-T scanner. After T1-
       and T2-weighted images were obtained, proton spectra were performed
       using voxels of interest (3.4 cm3) in the deep parietooccipital white
       matter. Peaks were identified as N-acetyl-aspartate (2.0 ppm), creatine
       and phosphocreatine (3.0 ppm), choline (3.2 ppm), and inositol (3.5
       ppm). Peak areas were used to calculate metabolic ratios:
       N-acetyl-aspartate to creatine, inositol to creatine, and creatine to
       choline. RESULTS: All newborns of HIV-positive mothers had abnormal
       proton spectra compared with control infants; a nonspecific amino acid
       peak in the 2.1- to 2.6-ppm area was elevated, broad, and overlapping
       the N-acetyl-aspartate peak in all the HIV-exposed newborns and in only
       1 of the 5 control newborns. The choline-to-creatine ratio was higher in
       HIV-exposed newborns at 2.3 +/- 0.4 (normal term, 0.9 +/- 0.3), as was
       the N-acetyl-aspartate-to-creatine ratio at 2.6 +/- 0.9 (for control
       subjects, 1.2 +/- 0.4). MR images from these brain regions were all
       considered normal. Because acquired immunodeficiency syndrome develops
       in only a small fraction of neonates born to HIV-seropositive mothers,
       the above spectral abnormalities found in all our subjects may result
       from indirect effects of HIV, such as intrauterine growth retardation.
       CONCLUSIONS: These findings indicate that proton MR spectroscopy might
       play an important role in detecting early central nervous system
       complications in newborns of HIV-seropositive mothers.
 DE    Aspartic Acid/ANALOGS & DERIVATIVES/METABOLISM  AIDS Dementia
       Complex/*DIAGNOSIS  Choline/METABOLISM  Diagnosis, Differential  Disease
       Transmission, Vertical  Energy Metabolism/*PHYSIOLOGY  Female  Fetal
       Growth Retardation/DIAGNOSIS  Human  HIV
       Seropositivity/*DIAGNOSIS/TRANSMISSION  Infant, Newborn
       Inositol/METABOLISM  Magnetic Resonance Imaging/*METHODS  Male  Nuclear
       Magnetic Resonance/*METHODS  Occipital Lobe/PATHOLOGY  Parietal
       Lobe/PATHOLOGY  Phosphocreatine/METABOLISM  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).