Document 0799
 DOCN  M9550799
 TI    Serum IL-10 levels in HIV-positive subjects: correlation with CDC
       stages.
 DT    9505
 AU    Ameglio F; Cordiali Fei P; Solmone M; Bonifati C; Prignano G; Giglio A;
       Caprilli F; Gentili G; Capobianchi MR; Laboratory of Clinical Pathology,
       San Gallicano Institute, Roma,; Italy.
 SO    J Biol Regul Homeost Agents. 1994 Apr-Jun;8(2):48-52. Unique Identifier
       : AIDSLINE MED/95167997
 AB    HIV-1 infection and the HIV gp120 have been shown to induce an IL-10
       increase in cultured peripheral blood mononuclear cells. Furthermore,
       the expression of this cytokine has been reported to increase in
       lymphnodes of infected patients along the disease course, and a shift
       from the TH-1 towards the TH-0/TH-2 phenotypes (with subsequent IL-10
       release) has been hypothesized to underly AIDS progression. In this
       study the serum IL-10 levels found in 30 HIV-negative controls and in 65
       HIV-positive patients, untreated with AZT and negative for HBsAg and
       HCV-Ab have been compared, using a commercial, competitive ELISA method
       based on a polyclonal anti-IL-10 serum. With this test, HIV-positive sea
       showed IL-10 levels significantly higher than those found in the
       controls. In addition the IL-10 levels progressively increased in the
       subsequent CDC stages, without further changes from the stage III to the
       stage IV. Accordingly, patients evaluated two times in CDC stage II,
       with a time interval of at least one year, showed significant IL-10
       increases, even more pronounced when the same patients passed from CDC
       stage II to stage III. Furthermore, a significant, negative correlation
       was observed between the circulating IL-10 levels and the patients'
       CD4/CD8 ratios. These data may be important from a clinical point of
       view since IL-10 monitoring could be considered as a surrogate marker
       for evaluating the disease progression. In addition, several
       immunological abnormalities present in HIV positive patients, such as
       the monocyte/macrophage impairment and the hypergammaglobulinemia could
       be related to the enhanced IL-10 expression.
 DE    Adult  Biological Markers/BLOOD  CD4-CD8 Ratio  Female  Human  HIV
       Infections/CLASSIFICATION/ETIOLOGY/*IMMUNOLOGY  *HIV-1
       Interleukin-10/*BLOOD  Male  Middle Age  Time Factors  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).