Document 0807
 DOCN  M9550807
 TI    Thymus involvement in murine acquired immunodeficiency (MAIDS).
 DT    9505
 AU    Colombi S; Deprez M; De Leval L; Humblet C; Greimers R; Defresne MP;
       Boniver J; Moutschen M; Laboratory of Pathology, University of Liege,
       Belgium.
 SO    Thymus. 1994;23(1):27-37. Unique Identifier : AIDSLINE MED/95167709
 AB    Due to self-renewal of the peripheral pool of T-cells, adult thymectomy
       has normally little influence on immunocompetence. However, thymus might
       play a more important role in the setting of viral-induced cytopathic
       effects on T-cells in the periphery. Therefore, thymus weight, cell
       numbers, and subset distribution were sequentially analysed after
       infection with RadLV-Rs, a viral mixture known to induce murine
       retrovirus induced immunodeficiency (MAIDS). Infection induced thymic
       atrophy (concerning organ weight as well as total cell number) which
       culminated seven weeks after inoculation. The atrophic process mostly
       reflected the depletion of double positive CD4+ CD8+ cells since their
       proportion sharply decreased around week 6. Single positive T-cells were
       less affected by the process. The proportion of B-cells progressively
       increased. Surprisingly, there was a strong correlation between the
       extent of atrophy and the frequency of B-cells in the thymus. Finally,
       an abnormal CD4+ T-cell subset lacking Thy-1 and previously described in
       the periphery also appeared in the thymus and its frequency was strongly
       correlated with the expansion of B-cells in this organ.
 DE    Animal  Antigens, Thy-1/IMMUNOLOGY  B-Lymphocytes/IMMUNOLOGY  Carrier
       Proteins/BIOSYNTHESIS  Cell Differentiation/IMMUNOLOGY  Flow Cytometry
       Male  Mice  Mice, Inbred C57BL  Murine Acquired Immunodeficiency
       Syndrome/*IMMUNOLOGY/VIROLOGY  Radiation Leukemia Virus  Receptors, Cell
       Surface/BIOSYNTHESIS  Receptors, Lymphocyte Homing/BIOSYNTHESIS
       Support, Non-U.S. Gov't  T-Lymphocyte Subsets/*IMMUNOLOGY/VIROLOGY
       Thymus Gland/*PATHOLOGY/VIROLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).