Document 0839
 DOCN  M9550839
 TI    Expression of the Runt domain-encoding PEBP2 alpha genes in T cells
       during thymic development.
 DT    9505
 AU    Satake M; Nomura S; Yamaguchi-Iwai Y; Takahama Y; Hashimoto Y; Niki M;
       Kitamura Y; Ito Y; Department of Viral Oncology, Kyoto University,
       Japan.
 SO    Mol Cell Biol. 1995 Mar;15(3):1662-70. Unique Identifier : AIDSLINE
       MED/95166251
 AB    The PEBP2 alpha A and PEBP2 alpha B genes encode the DNA-binding subunit
       of a murine transcription factor, PEBP2, which is implicated as a
       T-cell-specific transcriptional regulator. These two related genes share
       the evolutionarily conserved region encoding the Runt domain. PEBP2
       alpha B is the murine counterpart of human AML1, which is located at the
       breakpoints of the 8;21 and 3;21 chromosome translocations associated
       with acute myeloid leukemia. Northern (RNA) blots of various adult mouse
       tissues revealed that the levels of expression of both genes were most
       prominent in the thymus. Furthermore, transcripts of PEBP2 alpha A and
       mouse AML1/PEBP2 alpha B were detected in T lymphocytes in the thymuses
       from day 16 embryos and newborns, as well as 4-week-old adult mice, by
       in situ hybridization. The expression of the genes persisted in
       peripheral lymph nodes of adult mice. The transcripts were detected in
       all the CD4- CD8-, CD4+ CD8+, CD4+ CD8-, and CD4- CD8+ cell populations.
       The results indicated that both genes are expressed in T cells
       throughout their development, supporting the notion that PEBP2 is a
       T-cell-specific transcription factor. Transcripts of mouse AML1/PEBP2
       alpha B were also detected in day 12 fetal hematopoietic liver and in
       the bone marrow cells of newborn mice. The implication of mouse
       AML1/PEBP2 alpha B expression in hematopoietic cells other than those of
       T-cell lineage is discussed in relation to myeloid leukemogenesis.
 DE    Acute Disease  Aging/*METABOLISM  Animal  Animals, Newborn  Antisense
       Elements (Genetics)  Base Sequence  Blotting, Northern  Bone
       Marrow/METABOLISM  Chromosomes, Human, Pair 21  Chromosomes, Human, Pair
       3  Chromosomes, Human, Pair 8  Conserved Sequence  CD4-Positive
       T-Lymphocytes/METABOLISM  CD8-Positive T-Lymphocytes/METABOLISM
       DNA-Binding Proteins/*BIOSYNTHESIS/*GENETICS  Embryo  Evolution  Human
       Leukemia, Myeloid/GENETICS  Liver/METABOLISM  Lymph Nodes/METABOLISM
       Male  Mice  Mice, Inbred C57BL  Mice, Inbred ICR  Mice, Nude  Neoplasm
       Proteins/BIOSYNTHESIS/GENETICS  Organ Specificity  Support, Non-U.S.
       Gov't  T-Lymphocytes/*METABOLISM/PHYSIOLOGY  Thymus Gland/GROWTH &
       DEVELOPMENT/*METABOLISM  Transcription Factors/*BIOSYNTHESIS/*GENETICS
       Transcription, Genetic  Translocation (Genetics)  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).