Document 0868
 DOCN  M9550868
 TI    Effect of the combination of interferon-alpha and stavudine on Friend
       virus infections in (B10.A x A.By)F1 mice.
 DT    9505
 AU    Sidwell RW; Warren RP; Okleberry K; Burger RA; Morrey JD; Department of
       Animal, Dairy and Veterinary Sciences, Utah State; University, Logan
       84322-5600.
 SO    J Infect Dis. 1995 Mar;171 Suppl 2:S93-8. Unique Identifier : AIDSLINE
       MED/95164995
 AB    The anti-Friend leukemia virus (FLV) effects of interferon-alpha-A/D
       (IFN-alpha) and 2',3'-didehydro-2',3'-dideoxythymidine (stavudine) used
       alone and in combination were examined in Mus dunni cells using a
       checkerboard-type experiment design. Strong antiviral synergy and a
       suggested cytotoxic synergy were seen. In two experiments to evaluate
       the effect of combining therapy with IFN-alpha and stavudine against FLV
       disease in the hybrid mouse strain (B10.A x A.By)F1, which is a strong
       producer of cytotoxic T cells, the drug combination resulted in better
       inhibition of FLV disease than did either drug used alone. Combination
       therapy inhibited splenomegaly, splenic virus infectious centers, plasma
       virus, and the virus-induced increase in hematocrit to a greater degree
       than did either drug alone. These data indicate that combination therapy
       with stavudine and IFN-alpha is effective in the treatment of murine
       retrovirus infections and may be of value in the treatment of human
       AIDS.
 DE    Acquired Immunodeficiency Syndrome/DRUG THERAPY  Animal  Cells, Cultured
       Cytotoxicity, Immunologic/DRUG EFFECTS  Drug Synergism  Drug Therapy,
       Combination  Female  *Friend Virus/DRUG EFFECTS
       Interferon-alpha/ADMINISTRATION & DOSAGE/PHARMACOLOGY/  *THERAPEUTIC USE
       Leukemia, Experimental/*DRUG THERAPY  Male  Mice  Mice, Inbred Strains
       Retroviridae Infections/*DRUG THERAPY  Stavudine/ADMINISTRATION &
       DOSAGE/PHARMACOLOGY/*THERAPEUTIC USE  Support, U.S. Gov't, P.H.S.  Tumor
       Virus Infections/*DRUG THERAPY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).