Document 0887
 DOCN  M9550887
 TI    Stress-induced glucocorticoid response modulates mononuclear cell
       trafficking during an experimental influenza viral infection.
 DT    9505
 AU    Hermann G; Beck FM; Sheridan JF; Department of Medical Microbiology and
       Immunology, College of; Medicine, Ohio State University, Columbus 43210.
 SO    J Neuroimmunol. 1995 Feb;56(2):179-86. Unique Identifier : AIDSLINE
       MED/95164656
 AB    The migration, distribution, and localization of lymphoid cells
       throughout the body is critical to the efficiency and development of the
       immune response. This study examined the role of endogenous
       glucocorticoids in mononuclear cell (MNC) trafficking during the
       development of an immune response to infection by influenza A/PR8 virus.
       Accumulation of MNC in the draining lymph nodes and at the site of virus
       replication (lungs) was studied in infected mice, and infected mice
       subjected to a stressor (physical restraint). The glucocorticoid
       antagonist, RU486, was used to block the activity of endogenous
       corticosterone during development of the immune response. PR8-infected
       mice demonstrated an elevation in circulating corticosterone regardless
       of whether they were treated with RU486 or a placebo. Thus, some
       'afferent' signal associated with the infection, and/or the immune
       response to infection, activated the hypothalamic-pituitary-adrenal axis
       (HPA) and was not subject to negative feedback regulation. The initial
       accumulation of MNC in the draining lymph nodes and lungs during
       infection, however, was independent of the glucocorticoid response. Our
       previous studies demonstrated that virally infected animals subjected to
       physical restraint had highly elevated plasma corticosterone levels,
       suppressed lymphadenopathy, and reduced accumulation of MNC in the
       lungs. In the present study, RU486 treatment restored cellularity to the
       draining lymph nodes and enhanced accumulation of MNC in lungs of
       stressed, A/PR8 virus-infected mice.
 DE    Animal  Cell Movement  Corticosterone/*BLOOD
       Influenza/*IMMUNOLOGY/PATHOLOGY  Leukocytes, Mononuclear/*PHYSIOLOGY
       Lung/PATHOLOGY  Lymph Nodes/PATHOLOGY  Male  Mice  Mice, Inbred C57BL
       Mifepristone/PHARMACOLOGY  Nitric Oxide/PHYSIOLOGY  Orthomyxoviruses
       Type A  Stress/*BLOOD  Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

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       protected by Copyright Law (Title 17, U.S.Code).