Document 0970
 DOCN  M9570970
 TI    Antisense research and applications.
 DT    9506
 AU    Anonymous; No affiliation given
 SO    Antisense Research and Applications. Crooke ST, Lebleu B, eds. Boca
       Raton, FL, CRC Press, 579 p., 1993.. Unique Identifier : AIDSLINE
       ICDB/95615469
 AB    It has only recently become accepted that oligonucleotides might have
       therapeutic utility. Although new to human therapeutics, small,
       diffusible, untranslated RNA transcripts, termed antisense RNAs, that
       pair to specific target RNAs at regions of complementarity, occur
       universally among prokaryotes and eukaryotes, serving to control target
       RNA function and expression. The antisense oligonucleotides finding
       therapeutic application are for the most part chemically modified and
       rendered resistant to nucleases; they also operate by sequence-specific
       binding to preselected cellular nucleic acids as their target. This book
       contains chapters by 56 international collaborating authors who survey
       the whole field of antisense research and its potential applications.
       The 32 chapters are grouped into nine sections: an introduction to the
       history and context of antisense drug discovery; a consideration of
       nucleic acid structure and function in relation to antisense drugs,
       including discussion of the 5' cap and the use of ribozymes; antisense
       RNAs occurring naturally; medicinal chemistry of oligonucleotides; first
       generation analogs, including methylphosphonates, phosphorothioates,
       alpha-oligonucleotides, P-chiral analogs, and other reactive
       derivatives; newer analogs, including those involving heterocyclic base
       modification, peptide nucleic acids, 2'-O-alkyl derivatives and various
       designer approaches; mechanisms of action of current synthetic
       oligonucleotides, which includes a discussion of higher order structures
       of HIV-1 RNAs as sites of drug action; pharmacokinetics and toxicology,
       largely of the major first generation drugs; and activities of current
       antisense drugs, which includes two chapters on antiviral action, one on
       their application in inflammation research and therapeutics, and one on
       inhibition of proto-oncogene expression in leukemic cells, which appears
       the CANCERLIT data base with the accession number ICDB/95615470. There
       is a subject index.
 DE    Antineoplastic Agents/CHEMISTRY/PHARMACOKINETICS/*THERAPEUTIC USE
       Antiviral Agents/CHEMISTRY/PHARMACOKINETICS/*THERAPEUTIC USE  Drug
       Design  Human  Oligonucleotides, Antisense/CHEMISTRY/PHARMACOKINETICS/
       *THERAPEUTIC USE  MONOGRAPH

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).