Document 0973
 DOCN  M9570973
 TI    Interleukin-6 (IL-6) and AIDS-Kaposi's sarcoma: a nested case-control
       study within the multicenter aids cohort study (MACS).
 DT    9506
 AU    Dourado MIC; Univ. of California, Los Angeles
 SO    Diss Abstr Int [B]; 55(3):843 1994. Unique Identifier : AIDSLINE
       ICDB/95607535
 AB    Since the beginning of the AIDS epidemic, a large research activity has
       focused on the etiology of Kaposi's sarcoma (KS) among HIV infected
       individuals. There are several hypothesized risk factors for AIDS-KS.
       However, there is not enough evidence supporting the existing
       hypotheses. Recently, a number of studies have confirmed that HIV or HIV
       encoded products can interact with human cells to produce immune
       cytokines. One of these cytokines is known as interleukin 6 (IL-6). In
       vitro observations have indicated that AIDS-KS cells can produce and
       respond to significant levels of IL-6. In addition, preliminary data
       suggest that IL-6 may be elevated among HIV infected individuals that
       subsequently develop AIDS-KS. The objective of this study was to
       investigate if elevated levels of IL-6 are associated with an increased
       incidence of AIDS-KS compared to other AIDS-defining illnesses such as
       opportunistic infections (OIs). We found that IL-6 levels were more
       prevalent among OIs than among AIDS-KS: OR was 0.4 (95% CI 0.2-0.9). The
       higher prevalence of IL-6 among controls could be explained by the
       association of higher levels of IL-6 with lower levels of CD4 T cell
       number. IL-6 might be a marker of immune dysfunction among HIV infected
       individuals. (Full text available from University Microfilms
       International, Ann Arbor, MI, as Order No. AAD94-20500)
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS/*METABOLISM
       Case-Control Studies  Human  Interleukin-6/*METABOLISM  Sarcoma,
       Kaposi's/ETIOLOGY/*METABOLISM  THESIS

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