Document 0975
 DOCN  M9570975
 TI    Immunologic and immunogenetic findings in patients affected by classic
       Kaposi's sarcoma in Sardinia (Meeting abstract).
 DT    9506
 AU    Cerimele D; Contu L; Cottoni F; Carcassi C; Dept. of Dermatology,
       Catholic University, Rome
 SO    Melanoma Res; 3:14 1993. Unique Identifier : AIDSLINE ICDB/95607242
 AB    106 patients affected by the classic type of Kaposi's sarcoma all born
       and living in North-East Sardinia have been studied. In 70 patients the
       disease was circumscribed and in 36 it was disseminated. Reduced number
       of CD4+ and increased number of CD8+ T-lymphocytes was observed; CD4:CD8
       ratio was 1.40 +/- 0.5 in the patients with circumscribed disease and
       0.77 +/- 0.2 in the patients with disseminated disease (1.78 +/- 0.6
       among the controls). Tuberculin reactivity was decreased in patients
       with the disseminated disease. 72 class I and class II HLA antigens have
       been typed. No significant variation of class I antigens was observed;
       among class II antigens DR-3, DR-5, DQw2 and DQw3 recurred with altered
       frequency. DR-3 frequency was 18.8% among all the patients against 53.6%
       among the controls; DR-5 was 56.6% against 23.1%; DQw2 21.7% against
       60%; DQw3 76.4% against 54.1%. The analysis of split DR-5 demonstrated
       that DR-11 was present in 41.9% of the patients against 77.8% of the
       controls and DR-12 was present in 58.1% of the patients against 22.2% of
       the controls. The concurrent decrease of CD4:CD8 ratio, of tuberculin
       reactivity and of HLA DR-3 antigen frequency in patients with the
       disseminated type of the disease could be interesting, also remembering
       that DR-3 is frequently observed in patients affected by autoimmune
       diseases.
 DE    CD4-CD8 Ratio  Histocompatibility Antigens Class I/IMMUNOLOGY
       Histocompatibility Antigens Class II/IMMUNOLOGY  Human
       Italy/EPIDEMIOLOGY  Sarcoma, Kaposi's/EPIDEMIOLOGY/*GENETICS/*IMMUNOLOGY
       Tuberculin Test  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).