Document 0014
 DOCN  M9580014
 TI    Fluctuations in serum amylase in patients with macroamylasemia.
 DT    9506
 AU    Sachdeva CK; Bank S; Greenberg R; Blumstein M; Weissman S; Long Island
       Jewish Medical Center, Albert Einstein College of; Medicine, Division of
       Gastroenterology, New Hyde Park, New York,; USA.
 SO    Am J Gastroenterol. 1995 May;90(5):800-3. Unique Identifier : AIDSLINE
       MED/95250761
 AB    OBJECTIVE: To report wide fluctuation of serum amylase in patients with
       macroamylasemia. It has generally been considered to remain constant.
       METHODS: Over the past 16 y, 18 patients have been diagnosed with
       macroamylasemia in our GI department. Of these, four patients were
       followed up with serial serum amylase determinations for a period of
       less than 1-4 y. Serum amylase was measured by the Phadebas amylase
       test. Serum macroamylase was measured by PEG precipitation technique.
       RESULTS: There was a wide fluctuation of serum amylase in three out of
       four patients. In the fourth patient, more persistent hyperamylasemia
       was noted during the shorter observation period. CONCLUSION: Marked
       fluctuation in serum amylase, ranging from 115 to 1160% in this study,
       may occur in patients with macroamylasemia. The reasons for these
       fluctuations are not clear but may be due to association-dissociation of
       amylase with serum proteins at variable time intervals. This
       fluctuation, especially when the amylase becomes normal (as in cases 1
       and 3), may lead to confusion in differentiating macroamylasemia from
       other causes of hyperamylasemia.
 DE    Acquired Immunodeficiency Syndrome/ENZYMOLOGY  Adult  Aged
       Amylases/*BLOOD  Case Report  Female  Human  Immunoproliferative Small
       Intestinal Disease/ENZYMOLOGY  Lymphoma/ENZYMOLOGY  Male  Middle Age
       JOURNAL ARTICLE

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