Document 0019
 DOCN  M9580019
 TI    Augmentation of c-fos and c-jun expression in transgenic mice carrying
       the human T-cell leukemia virus type-I tax gene.
 DT    9506
 AU    Iwakura Y; Tosu M; Yoshida E; Saijo S; Nakayama-Yamada J; Itagaki K;
       Asano M; Siomi H; Hatanaka M; Takeda T; et al; Institute of Medical
       Science, University of Tokyo, Japan.
 SO    Virus Genes. 1995 Jan;9(2):161-70. Unique Identifier : AIDSLINE
       MED/95250308
 AB    To analyze the effect of human T-cell leukemia virus type I (HTLV-I) on
       cellular gene expression and its relation to tumorigenesis, two lines of
       transgenic mice carrying the long terminal repeat (LTR)-env-pX-LTR
       regions of the HTLV-I genome were produced. The transgene was expressed
       in many organs, including the brain, salivary gland, spleen, thymus,
       skin, muscle, and mammary gland. We found that the expression of the
       c-fos and c-jun genes, but not of the lyn and c-myc genes, was augmented
       2- to 20-fold in histologically normal skin and muscle of these mice.
       The augmentation was tissue specific, suggesting the involvement of a
       cellular factor in the transgene action. In these mice, a three to seven
       times higher incidence of tumors was seen as compared with the control
       mice. These tumors included mesenchymal tumors, such as fibrosarcoma,
       neurofibroma, and lipoma, and adenocarcinomas of the mammary gland,
       salivary gland, and lung. The c-fos and c-jun genes were also activated
       in these tumors. The possible roles of elevated c-fos and c-jun gene
       expression in tumorigensis are discussed.
 DE    Animal  Female  *Gene Expression Regulation, Viral  Genes, env  *Genes,
       fos  *Genes, jun  *Genes, pX  Human  HTLV-I/*GENETICS  Male  Mice  Mice,
       Inbred C3H  Mice, Transgenic  Neoplasms, Experimental/GENETICS/VIROLOGY
       Repetitive Sequences, Nucleic Acid/GENETICS  Support, Non-U.S. Gov't
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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