Document 0020
 DOCN  M9580020
 TI    An analysis of the role of skin Langerhans cells (LC) in the cytoplasmic
       processing of HIV-1 peptides after peplotion transepidermal transfer and
       HLA class I presentation to CD8+ CTLs--an approach to immunization of
       humans.
 DT    9506
 AU    Becker Y; Department of Molecular Virology, Faculty of Medicine, Hebrew;
       University of Jerusalem, Israel.
 SO    Virus Genes. 1995 Jan;9(2):133-47. Unique Identifier : AIDSLINE
       MED/95250305
 AB    Skin Langerhans cells (LC) are antigen-presenting cells capable of
       expressing MHC class I and class II molecules on the plasma membrane.
       This molecular activity was reviewed to combine the knowledge of peptide
       presentation by MHC and HLA class I and class II molecules to prime CD8+
       cytotoxic T cells (CTLs) and CD4+ T helper cells, respectively. The
       possible utilization of the skin dendritic cells for the development of
       antiviral CTLs and antibodies by synthetic peptides modeled according to
       the motifs of peptides that naturally interact with the peptide binding
       grooves of the various HLA haplotypes is discussed and evaluated. It may
       be possible that the introduction of synthetic viral peptides with
       motifs to fit the HLA class I haplotypes of a human population to the
       skin dendritic cells will prime selectively the cellular or the humoral
       immune responses. This approach may provide a new vaccination technique
       that applies synthetic virus peptides as vaccines for the immunization
       of humans. The neuropeptide CGRP interacts with LC and modulates antigen
       presentation.
 DE    *Antigen Presentation  Dendritic Cells/IMMUNOLOGY  Histocompatibility
       Antigens Class I/IMMUNOLOGY  Histocompatibility Antigens Class
       II/IMMUNOLOGY  Human  HIV-1/*IMMUNOLOGY  Immunization  Langerhans
       Cells/*IMMUNOLOGY  Major Histocompatibility Complex  Skin/IMMUNOLOGY
       Support, Non-U.S. Gov't  Support, U.S. Gov't, Non-P.H.S.  T-Lymphocytes,
       Cytotoxic/*IMMUNOLOGY  T-Lymphocytes, Helper-Inducer/*IMMUNOLOGY  Viral
       Proteins/IMMUNOLOGY  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).