Document 0036
 DOCN  M9580036
 TI    [Thrombocytopenia associated with human immunodeficiency virus
       infection. Pathogenic significance of platelet autoimmunity phenomena]
 DT    9506
 AU    Carton Sanchez JA; Llorente de Jesus MR; Rodriguez Vicente P; Servicios
       de Medicina Interna (Infecciones) y Hematologia,; Hospital Central de
       Asturias (Nuestra Senora de Covadonga,; Oviedo.
 SO    Rev Clin Esp. 1995 Feb;195(2):78-82. Unique Identifier : AIDSLINE
       MED/95249778
 AB    OBJECTIVES. Several mechanisms in formation and destruction of platelets
       could be involved in thrombocytopenia associated with HIV infection
       (TP/HIV). This epidemiological study investigated the pathogenic role of
       immunoglobulins associated with platelets (IAP), circulant
       immunocomplexes (CIC) and anticardiolipin antibodies (ACA) in patients
       with TP/HIV. PATIENTS AND METHODS. A total of 207 adults patients
       infected with HIV were studied. Patients were classified as
       thrombocytopenic (platelet count < 100,000/mm3, n = 68); borderline
       thrombocytopenic (platelet count from 100,000 to 150,000/mm3, n = 23)
       and non-thrombopenic (platelet count > 150,000/m3, n = 116). IAP were
       investigated by an immunofluorescence technique with flow cytometry
       reading and eluate technique. CIC were investigated by C1q fixation
       measured by nephelometry. IgG-ACA determination was made with a
       commercially available ELISA technique. RESULTS. Prevalence of
       thrombocytopenia in the general cohort of seropositive patients was 16%.
       Fifteen per cent of these patients had severe TP. There were no
       significant differences in epidemiology or prognosis among patients with
       and without TP. Patients with TP/HIV had increase rates of IAP, CIC and
       ACA (78%, 42% and 89%). These parameters were also increased in a
       similar percentage of non-TP infected patients (73%, 52%, 94%
       respectively). No correlation was observed between platelet counts and
       values of these immunological phenomena. CONCLUSIONS. TP/HIV is common,
       mild, with no prognostic significance and occurs in an heterogeneous
       patient population. Immune phenomena associated with a decreased
       platelet survival occur nonspecifically and with an uncertain pathogenic
       meaning.
 DE    Adult  Blood Platelets/*IMMUNOLOGY  English Abstract  Female  Human  HIV
       Infections/*COMPLICATIONS  Incidence  Male  Odds Ratio
       Thrombocytopenia/COMPLICATIONS/EPIDEMIOLOGY/*IMMUNOLOGY  JOURNAL ARTICLE

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