Document 0043
 DOCN  M9580043
 TI    Synthesis and biological activity of pyrimidobenzodiazepine derivatives.
       New ring systems: triazolo- and tetrazolo-pyrimido-benzodiazepines.
 DT    9506
 AU    Dlugosz A; Department of Organic Chemistry, Medical University, Faculty
       of; Pharmacy, Wroclaw, Poland.
 SO    Pharmazie. 1995 Mar;50(3):180-2. Unique Identifier : AIDSLINE
       MED/95249628
 AB    New triazolo- and tetrazolo-pyrimidobenzodiazepines were synthesized and
       screened as anti-HIV, anticancer and immunosuppressive agents. Some of
       the compounds showed immunosuppressive activity, similar to or stronger
       than that of cyclosporine A.
 DE    Animal  Antibody Formation/DRUG EFFECTS  Antineoplastic Agents/CHEMICAL
       SYNTHESIS/PHARMACOLOGY  Antiviral Agents/CHEMICAL SYNTHESIS/PHARMACOLOGY
       Benzodiazepinones/*CHEMICAL SYNTHESIS/PHARMACOLOGY  Cells, Cultured
       Cyclosporine/PHARMACOLOGY  Drug Screening  Drug Screening Assays,
       Antitumor  Human  HIV-1/DRUG EFFECTS  IgM/BIOSYNTHESIS
       Immunosuppressive Agents/*CHEMICAL SYNTHESIS/PHARMACOLOGY  Mice
       Spleen/CYTOLOGY/IMMUNOLOGY  Support, Non-U.S. Gov't
       Tetrazoles/*CHEMICAL SYNTHESIS/PHARMACOLOGY  Triazoles/*CHEMICAL
       SYNTHESIS/PHARMACOLOGY  Tumor Cells, Cultured  JOURNAL ARTICLE

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