Document 0047
 DOCN  M9580047
 TI    Primary lymphomatous effusions in AIDS: a morphological,
       immunophenotypic, and molecular study.
 DT    9506
 AU    Green I; Espiritu E; Ladanyi M; Chaponda R; Wieczorek R; Gallo L; Feiner
       H; Department of Pathology, New York University Medical Center, New;
       York, USA.
 SO    Mod Pathol. 1995 Jan;8(1):39-45. Unique Identifier : AIDSLINE
       MED/95249511
 AB    Lymphomas were documented in pleural effusions or ascites in 18 human
       immunodeficiency virus-positive (HIV+) patients. Eleven of 12 with
       clinical data had acquired immunodeficiency syndrome before the
       diagnosis of lymphoma. In 13 of 15 with data available, a body cavity
       was the site of initial presentation of lymphoma. Cytological subtypes
       were large cell immunoblastic, n = 7; large cell anaplastic, n = 6; and
       large cell NOS, n = 5. The high incidence of anaplastic large cell
       lymphoma and the conspicuous absence of Burkitt's lymphoma differ
       strikingly from HIV-associated lymphomas generally.
       Immunophenotypically, two cases were B-cell (CD19/20+, sIg+, CD/5-), one
       was T-cell (CD3+, CD5+, CD4+, CD8-, CD19/20-, sIg-), and 15 were null
       (CD45+, HLA-DR+ CD19/20-, sIg-, CD3/5-). This 83% incidence of null
       immunophenotype contrasts sharply with a 9% incidence among 35
       tissue-based lymphomas in HIV+ patients that were similarly studied and
       a 0% null immunophenotype among 11 lymphomatous effusions in patients
       without HIV risk factors. Seven of the 18 HIV-associated lymphomas
       expressed CD30. Four of five cases with null immunophenotype showed Ig
       heavy-chain gene rearrangement, two had clonal Epstein-Barr virus
       integration, and none had MYC protooncogene rearrangement. These cases
       belong to a subgroup of high-grade HIV-associated lymphomas that occur
       in the setting of profound immunosuppression in which immunoblastic
       morphology predominates and MYC rearrangement is encountered only
       infrequently.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Adult  Aged  Aged, 80
       and over  Comparative Study  Female  Gene Rearrangement  Human  HIV
       Seropositivity/*COMPLICATIONS  Immunohistochemistry  Immunophenotyping
       Lymphoma, Non-Hodgkin's/*COMPLICATIONS/GENETICS/IMMUNOLOGY/  PATHOLOGY
       Male  Middle Age  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).