Document 0072
 DOCN  M9580072
 TI    Intrarectal inoculation of macaques by the simian immunodeficiency
       virus, SIVmne E11S: CD4+ depletion and AIDS.
 DT    9506
 AU    Kuller L; Benveniste RE; Tsai CC; Clark EA; Polacino P; Watanabe R;
       Overbaugh J; Katze MG; Morton WR; Regional Primate Research Center,
       University of Washington,; Seattle 98195, USA.
 SO    J Med Primatol. 1994 Sep;23(7):397-409. Unique Identifier : AIDSLINE
       MED/95248529
 AB    Macaca nemestrina and Macaca fascicularis were inoculated with various
       doses of a single-cell clone of SIVmne-infected HuT 78 cells (E11S) by
       both the intravenous and intrarectal routes. Animals inoculated
       intravenously at each dose seroconverted and virus was isolated from
       peripheral blood mononuclear cells, but only the high-dose intrarectally
       exposed macaques became viremic and seroconverted. However, some
       seronegative, virus isolation negative intrarectally inoculated macaques
       showed evidence of infection and disease.
 DE    Animal  Antibodies, Viral/BLOOD  Base Sequence  Blotting, Western  Clone
       Cells  Comparative Study  CD4-Positive T-Lymphocytes/*IMMUNOLOGY  DNA
       Primers  *Lymphocyte Depletion  Lymphocyte Subsets/IMMUNOLOGY  Macaca
       fascicularis  Macaca nemestrina  Molecular Sequence Data  Polymerase
       Chain Reaction/METHODS  Rectum/*VIROLOGY  Repetitive Sequences, Nucleic
       Acid  Simian Acquired Immunodeficiency Syndrome/IMMUNOLOGY/
       *PHYSIOPATHOLOGY/TRANSMISSION  Support, U.S. Gov't, P.H.S.
       *SIV/GENETICS/ISOLATION & PURIF  Time Factors  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).