Document 0073
 DOCN  M9580073
 TI    Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 3.
       Dipyrido[2,3-b:2',3'-e]diazepinones.
 DT    9506
 AU    Proudfoot JR; Patel UR; Kapadia SR; Hargrave KD; Boehringer Ingelheim
       Pharmaceuticals, Inc., Ridgefield,; Connecticut 06877, USA.
 SO    J Med Chem. 1995 Apr 14;38(8):1406-10. Unique Identifier : AIDSLINE
       MED/95248522
 AB    We have explored the potential of derivatives of the
       dipyrido[2,3-b:2',3'-e][1,4]diazepinone ring system as inhibitors of
       HIV-1 reverse transcriptase (RT). These compounds are isomeric to the
       potent RT inhibitor nevirapine and are available via a novel Smiles
       rearrangement on intermediates used for the synthesis of nevirapine
       analogs. Derivatives of this isomeric series are weaker inhibitors of RT
       than corresponding nevirapine analogs, although with appropriate
       substitution of the A- and C-pyridine rings activity can be improved.
 DE    Antiviral Agents/CHEMISTRY/*PHARMACOLOGY
       Azepines/CHEMISTRY/*PHARMACOLOGY  HIV-1/DRUG EFFECTS/*ENZYMOLOGY
       Nuclear Magnetic Resonance  Reverse Transcriptase/*ANTAGONISTS & INHIB
       JOURNAL ARTICLE

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