Document 0086
 DOCN  M9580086
 TI    Simian immunodeficiency virus (SIV)-specific CTL in cerebrospinal fluid
       and brains of SIV-infected rhesus macaques.
 DT    9506
 AU    von Herrath M; Oldstone MB; Fox HS; Department of Neuropharmacology,
       Scripps Research Institute, La; Jolla, CA 92037, USA.
 SO    J Immunol. 1995 May 15;154(10):5582-9. Unique Identifier : AIDSLINE
       MED/95248126
 AB    Simian immunodeficiency virus (SIV)-specific CD8+ CTL were isolated from
       blood, cerebrospinal fluid, and brains of rhesus macaques infected i.v.
       with SIV. CTL were found as early as 1 wk postinfection and their
       appearance correlated with a decrease of viral Ag (p27) found in the
       blood. CTL isolated from cerebrospinal fluid and/or brain often
       recognized different viral proteins than CTL isolated from blood,
       suggesting either a unique migratory pattern to the central nervous
       system or a difference in activation/retention of lymphocytes in these
       compartments.
 DE    Amino Acid Sequence  Animal  Brain/CYTOLOGY/*IMMUNOLOGY  Cerebrospinal
       Fluid/CYTOLOGY/*IMMUNOLOGY  Cytotoxicity Tests, Immunologic  Lymphoid
       Tissue/CYTOLOGY  Macaca mulatta  Male  Molecular Sequence Data  Simian
       Acquired Immunodeficiency Syndrome/CEREBROSPINAL FLUID/  *IMMUNOLOGY
       Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  SIV/*IMMUNOLOGY
       T-Lymphocytes, Cytotoxic/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).