Document 0095
 DOCN  M9580095
 TI    Internal quality assurance in a clinical virology laboratory. II.
       Internal quality control.
 DT    9506
 AU    Gray JJ; Wreghitt TG; McKee TA; McIntyre P; Roth CE; Smith DJ; Sutehall
       G; Higgins G; Geraghty R; Whetstone R; et al; Clinical Microbiology and
       Public Health Laboratory, Addenbrooke's; Hospital, Cambridge.
 SO    J Clin Pathol. 1995 Mar;48(3):198-202. Unique Identifier : AIDSLINE
       MED/95247915
 AB    AIMS--In April 1991 additional quality control procedures were
       introduced into the virology section of the Clinical Microbiology and
       Public Health Laboratory, Cambridge. Internal quality control (IQC)
       samples were gradually included in the serological assays performed in
       the laboratory and supplemented kit controls and standard sera.
       METHODS--From April 1991 to December 1993, 2421 IQC procedures were
       carried out with reference sera. RESULTS--The IQC samples were evaluated
       according to the Westgard rules. Violations were recorded in 60 of 1808
       (3.3%) controls and were highest in the IQC samples of complement
       fixation tests (25/312 (8%) of controls submitted for complement
       fixation tests). CONCLUSIONS--The inclusion of IQC samples in the
       serological assays performed in the laboratory has highlighted batch to
       batch variation in commercial assays. The setting of acceptable limits
       for the IQC samples has increased confidence in the validity of assay
       results.
 DE    Complement Fixation Tests/STANDARDS  England  Enzyme-Linked
       Immunosorbent Assay/STANDARDS  Human  HIV-1/ISOLATION & PURIF
       HIV-2/ISOLATION & PURIF  Laboratories, Hospital/*STANDARDS  Quality
       Control  Virology/*STANDARDS  Viruses/ISOLATION & PURIF  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).