Document 0113
 DOCN  M9580113
 TI    Local Th1-like responses are induced by intravaginal infection of mice
       with the mouse pneumonitis biovar of Chlamydia trachomatis.
 DT    9506
 AU    Cain TK; Rank RG; Department of Microbiology and Immunology, University
       of Arkansas; for Medical Sciences, Little Rock 72205, USA.
 SO    Infect Immun. 1995 May;63(5):1784-9. Unique Identifier : AIDSLINE
       MED/95247261
 AB    A critical role for cell-mediated immunity (CMI) has been demonstrated
       for effecting the resolution of genital infections of mice infected
       intravaginally with the mouse pneumonitis biovar of Chlamydia
       trachomatis (MoPn). However, little is known about expression of CMI in
       the murine genital tract. The mouse MoPn model was used to examine CMI
       responses in the genital tract and associated lymph nodes during the
       course of infection. MoPn-specific lymphocytes were present in the
       genital mucosa, with the maximum level of proliferation in response to
       MoPn at 3 weeks postinfection. MoPn-stimulated cells secreting gamma
       interferon were also detected in the cells from the genital mucosa, but
       few interleukin-4-secreting cells were seen at any time postinfection,
       indicating the induction of a Th1-like response in the cells of the
       genital mucosa. The iliac node draining the genital tract was the major
       node stimulated as a result of a genital infection and exhibited a
       predominant Th1-like pattern of cytokine secretion as well. Mesenteric
       lymph node cells demonstrated poor proliferative responses to MoPn and
       few antigen-stimulated cytokine-secreting cells after the primary
       infection. However, 7 days after a second infection administered 50 days
       following the primary infection, there was a marked increase in both
       proliferative responses and the frequencies of MoPn-stimulated gamma
       interferon- and interleukin-4-secreting cells. These studies provided
       information regarding the local CMI response to MoPn in mice which may
       prove valuable in the development of vaccination strategies for the
       prevention of chlamydial genital infections.
 DE    Animal  Chlamydia trachomatis/CLASSIFICATION/*IMMUNOLOGY  Chlamydia
       Infections/*IMMUNOLOGY  Cytokines/SECRETION  Disease Models, Animal
       Female  Immunity, Cellular/*IMMUNOLOGY  Lung Diseases,
       Interstitial/MICROBIOLOGY  Lymph Nodes/CYTOLOGY/IMMUNOLOGY  Lymphocyte
       Transformation  Mice  Mice, Inbred BALB C  Mucous
       Membrane/CYTOLOGY/IMMUNOLOGY  Spleen/CYTOLOGY/IMMUNOLOGY  Support,
       Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  Th1 Cells/*IMMUNOLOGY
       Vaginal Diseases/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).