Document 0117
 DOCN  M9580117
 TI    Nasopharyngeal carriage of Staphylococcus aureus and carriage of
       tetracycline-resistant strains associated with HIV-seropositivity.
 DT    9506
 AU    Amir M; Paul J; Batchelor B; Kariuki S; Ojoo J; Waiyaki P; Gilks C;
       Wellcome Trust Research Laboratories, Kilifi, Kenya.
 SO    Eur J Clin Microbiol Infect Dis. 1995 Jan;14(1):34-40. Unique Identifier
       : AIDSLINE MED/95246769
 AB    The aim of this prospective study was to investigate the relationship
       between carriage of antibiotic-resistant Staphylococcus aureus and
       infection with the human immunodeficiency virus (HIV). A total of 554
       pernasal swabs was taken during a six-month period from 554 adult
       patients attending three outpatient clinics and from inpatients from a
       hospital in Nairobi, Kenya. Overall, 121 swabs (22%) yielded
       Staphylococcus aureus, there being significantly higher carriage in
       HIV-positive patients (71/264, 27%) than in HIV-negative patients
       (50/290, 17%); p = 0.008. Antimicrobial resistance rates were determined
       for 110 isolates and were high for penicillin (91%) and tetracycline
       (72%) and low for erythromycin (8%), methicillin (3%), gentamicin (5%)
       and chloramphenicol (0%). Genetic analysis showed plasmids in the range
       of 24-42 MDa to be associated with beta-lactamase production and
       plasmids in the range of 3-5 MDa to be associated with resistance to
       tetracycline, erythromycin and trimethoprim. All nine
       erythromycin-resistant strains were from HIV-positive patients (p =
       0.02). There was a significant association of tetracycline resistance
       with HIV seropositivity (p = 0.002). The association of HIV
       seropositivity with Staphylococcus aureus carriage and carriage of
       antibiotic-resistant strains against the background of the HIV epidemic
       are of relevance in individual patient care and raise concern for public
       health.
 DE    Adult  Africa, Eastern  Bacteriophage Typing  *Carrier State  Female
       Human  HIV Seropositivity/COMPLICATIONS/*MICROBIOLOGY  Male  Microbial
       Sensitivity Tests  Nasopharynx/MICROBIOLOGY  Plasmids/ANALYSIS
       Prospective Studies  Staphylococcal Infections/*COMPLICATIONS
       Staphylococcus aureus/CLASSIFICATION/DRUG EFFECTS/*ISOLATION &  PURIF
       Tetracycline Resistance  JOURNAL ARTICLE

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