Document 0136
 DOCN  M9580136
 TI    Herpes simplex virus brainstem encephalitis in an AIDS patient.
 DT    9506
 AU    Hamilton RL; Achim C; Grafe MR; Fremont JC; Miners D; Wiley CA;
       University of California, San Diego, Department of Pathology;
       (Neuropathology), La Jolla, USA.
 SO    Clin Neuropathol. 1995 Jan-Feb;14(1):45-50. Unique Identifier : AIDSLINE
       MED/95246369
 AB    We report a case of a virulent, atypical herpes simplex infection in the
       brainstem of a patient with Acquired Immune Deficiency Syndrome (AIDS)
       which was characterized by demyelination and oligodendroglial tropism.
       At autopsy the brainstem showed demyelination. Immunocytochemistry, in
       situ hybridization, and electron microscopy confirmed the presence of
       herpes simplex virus (HSV). Viral cultures demonstrated HSV type 1.
       Neuroinvasiveness and neurovirulence were studied by intraperitoneal
       inoculation of susceptible mouse strains (A/J and Balb/cByJ) with
       different viral titers. The LD50 of the clinical isolate was 5 orders of
       magnitude greater than the LD50 of a laboratory HSV strain (HSV type 1
       KOS). The brains of the mice inoculated with the clinical isolate showed
       brainstem and cerebellar demyelination.
 DE    Adult  Animal  AIDS-Related Opportunistic Infections/*VIROLOGY  Brain
       Stem/*VIROLOGY  Case Report  Cell Line  Encephalitis, Viral/*VIROLOGY
       Human  Male  Mice  Mice, Inbred A  Mice, Inbred BALB C  Mice, Inbred
       C57BL  Simplexvirus/*ISOLATION & PURIF/PATHOGENICITY  Support, Non-U.S.
       Gov't  Support, U.S. Gov't, P.H.S.  Virulence  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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