Document 0160
 DOCN  M9580160
 TI    Smoldering adult T-cell leukemia with B-cell lymphoma and early gastric
       cancer.
 DT    9506
 AU    Kodama M; Matsuoka H; Maeda K; Suzuki M; Okayama A; Uno H; Tachibana N;
       Komada N; Kouno M; Ohshima K; et al; Second Department of Internal
       Medicine, Miyazaki Medical School.
 SO    Intern Med. 1995 Feb;34(2):118-21. Unique Identifier : AIDSLINE
       MED/95245003
 AB    We report a case of smoldering adult T-cell leukemia (ATL) with B-cell
       lymphoma and early gastric cancer. A 64-year-old man was admitted to our
       hospital because of proteinuria and hypergammaglobulinemia. Systemic
       lymphadenopathy, flower cells in peripheral white blood cells, and
       hypergammaglobulinemia with monoclonal gammopathy (IgA, lambda type)
       were found. As Southern blot analysis revealed monoclonal integration of
       human T-lymphotrophic virus type I proviral DNA in peripheral blood
       mononuclear cells, he was diagnosed as having smoldering ATL. The tissue
       specimen of an inguinal lymph node showed proliferation of abnormal
       lymphocytes which were stained with anti-lambda antibody, indicating
       B-cell lymphoma. A polypoid lesion in the stomach was histologically
       diagnosed as early gastric cancer.
 DE    Case Report  Human  HTLV-I Infections/*COMPLICATIONS/PATHOLOGY
       Leukemia, T-Cell, Chronic/PATHOLOGY/*VIROLOGY  Lymphoma,
       B-Cell/PATHOLOGY/*VIROLOGY  Male  Middle Age  Stomach
       Neoplasms/PATHOLOGY/*VIROLOGY  JOURNAL ARTICLE

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