Document 0173
 DOCN  M9580173
 TI    Infection due to parvovirus B19 in patients infected with human
       immunodeficiency virus.
 DT    9506
 AU    Chernak E; Dubin G; Henry D; Naides SJ; Hodinka RL; MacGregor RR;
       Friedman HM; Department of Medicine, Hospital of the University of;
       Pennsylvania.
 SO    Clin Infect Dis. 1995 Jan;20(1):170-3. Unique Identifier : AIDSLINE
       MED/95244728
 AB    Parvovirus B19 has been described as a cause of chronic anemia in
       immunosuppressed patients, including those infected with human
       immunodeficiency virus (HIV). In this study serological assays and the
       polymerase chain reaction (PCR) were used to establish the prevalence of
       both prior and active infection due to parvovirus B19 among a general
       population of 105 HIV-infected individuals (cohort I) and among 22
       HIV-infected patients with anemia (cohort II). Eight individuals in
       cohort I (7.6%) had IgG antibodies to parvovirus B19, while none had
       B19-specific IgM antibodies. In cohort II, four patients (18.2%) had
       B19-specific IgG antibodies and none had IgM antibodies. Only one person
       in cohort I (0.95%) and one person in cohort II (4.5%) had evidence on
       PCR of persistent infection with parvovirus B19; both of these patients
       lacked IgG and IgM antibodies to parvovirus. Both individuals with B19
       viremia were anemic and had CD4 lymphocyte counts suggesting advanced
       immunosuppression (< 50/mm3). The observed low prevalences of B19
       seropositivity and active B19 infection differ from the rates documented
       in previous studies and indicate that infection with parvovirus B19 is
       uncommon in some groups of HIV-infected patients.
 DE    Adult  Aged  Anemia/COMPLICATIONS/IMMUNOLOGY/VIROLOGY  Antibodies,
       Viral/BLOOD  AIDS-Related Opportunistic
       Infections/*COMPLICATIONS/IMMUNOLOGY/  VIROLOGY  Erythema
       Infectiosum/*COMPLICATIONS/IMMUNOLOGY/VIROLOGY  Female  Human  IgG/BLOOD
       IgM/BLOOD  Male  Middle Age  Parvovirus B19,
       Human/GENETICS/IMMUNOLOGY/ISOLATION & PURIF  Polymerase Chain Reaction
       Support, Non-U.S. Gov't  Support, U.S. Gov't, Non-P.H.S.  Support, U.S.
       Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).