Document 0176
 DOCN  M9580176
 TI    Alcohol abuse and HIV infection have additive effects on frontal cortex
       function as measured by auditory evoked potential P3A latency.
 DT    9506
 AU    Fein G; Biggins CA; MacKay S; Department of Psychiatry, University of
       California, San; Francisco, USA.
 SO    Biol Psychiatry. 1995 Feb 1;37(3):183-95. Unique Identifier : AIDSLINE
       MED/95244709
 AB    Both alcohol and human immunodeficiency virus (HIV) infection have been
       shown to produce central nervous system (CNS) morbidity in frontal brain
       regions. The degree to which the CNS morbidity in HIV infection, as it
       affects frontal cortex function, may be preferentially increased by
       alcohol abuse was examined using the auditory P3A evoked potential. The
       P3A indexes an orienting response, maximal over frontal cortex that
       occurs when novel nontarget stimuli are presented in the midst of a
       target detection paradigm. Four groups of subjects were compared: HIV+
       alcohol abusers, HIV+ light/nondrinkers, HIV- alcohol abusers, and HIV-
       light/nondrinkers. The alcohol abuser and light/nondrinker HIV+ groups
       were matched on percent CD4 lymphocytes, insuring that the results
       reflected specific CNS effects and were not a result of differences
       between the groups in the degree of systemic immune suppression. Alcohol
       abuse and HIV infection had at least additive effects on P3A latency,
       consistent with alcohol abuse worsening the effect of HIV disease on
       frontal cortex function. Post-hoc analyses suggested that concomitant
       alcohol abuse results in the effects of HIV infection on P3A latency
       becoming manifest earlier in the HIV disease process.
 DE    Acoustic Stimulation  Adult  Alcohol Drinking/ADVERSE EFFECTS
       Alcoholism/COMPLICATIONS/*PHYSIOPATHOLOGY  Arousal/PHYSIOLOGY  AIDS
       Dementia Complex/COMPLICATIONS/*PHYSIOPATHOLOGY  Bisexuality  Brain
       Mapping/INSTRUMENTATION  Dominance, Cerebral/PHYSIOLOGY
       Electroencephalography/INSTRUMENTATION  Evoked Potentials,
       Auditory/*PHYSIOLOGY  Frontal Lobe/*PHYSIOPATHOLOGY  Homosexuality, Male
       Human  HIV Infections/COMPLICATIONS/*PHYSIOPATHOLOGY  Male  Reaction
       Time/*PHYSIOLOGY  Signal Processing, Computer-Assisted/INSTRUMENTATION
       Support, U.S. Gov't, Non-P.H.S.  Support, U.S. Gov't, P.H.S.  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).