Document 0001
 DOCN  M9590001
 TI    Inhibition of tumor necrosis factor by curcumin, a phytochemical.
 DT    9509
 AU    Chan MM; Department of Biological Sciences, Rutgers, State University
       of; New Jersey, Piscataway 08855-1059, USA.
 SO    Biochem Pharmacol. 1995 May 26;49(11):1551-6. Unique Identifier :
       AIDSLINE MED/95305858
 AB    Curcumin, contained in the rhizome of the plant Curcuma longa Linn, is a
       naturally occurring phytochemical that has been used widely in India and
       Indonesia for the treatment of inflammation. The pleiotropic cytokine
       tumor necrosis factor-alpha (TNF) induces the production of
       interleukin-1 beta (IL-1), and, together, they play significant roles in
       many acute and chronic inflammatory diseases. They have been implicated
       in the pathogenesis of intracellular parasitic infections,
       atherosclerosis, AIDS and autoimmune disorders. This report shows that,
       in vitro, curcumin, at 5 microM, inhibited lipopolysaccharide
       (LPS)-induced production of TNF and IL-1 by a human monocytic macrophage
       cell line, Mono Mac 6. In addition, it demonstrates that curcumin, at
       the corresponding concentration, inhibited LPS-induced activation of
       nuclear factor kappa B and reduced the biological activity of TNF in
       L929 fibroblast lytic assay.
 DE    Anti-Inflammatory Agents/*PHARMACOLOGY  Cell Line  Cell Survival
       Curcumin/*PHARMACOLOGY  Human  Interleukin-1/ANTAGONISTS & INHIB
       Lipopolysaccharides  Macrophages/DRUG EFFECTS/METABOLISM  NF-kappa
       B/ANTAGONISTS & INHIB  Support, Non-U.S. Gov't  Tumor Necrosis
       Factor/*ANTAGONISTS & INHIB  JOURNAL ARTICLE

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