Document 0033
 DOCN  M9590033
 TI    Circulating gamma delta-T-cell-receptor-positive lymphocytes in
       sarcoidosis.
 DT    9509
 AU    Shigehara K; Shijubo N; Nakanishi F; Hirasawa M; Inuzuka M; Ohmichi M;
       Hiraga Y; Abe S; Third Department of Internal Medicine, Sapporo Medical
       University; School of Medicine, Japan.
 SO    Respiration. 1995;62(2):84-8. Unique Identifier : AIDSLINE MED/95304184
 AB    We investigated phenotypic surface markers of peripheral blood
       lymphocytes including expression of gamma delta T cell receptor (TCR
       gamma delta) in 185 patients with sarcoidosis and 42 normal subjects.
       The proportion of TCR gamma delta+ lymphocytes in peripheral blood of
       patients with sarcoidosis (5.5 +/- 5.4%) was significantly higher than
       in normal subjects (3.6 +/- 2.2%; p < 0.05). A number of patients with
       sarcoidosis had prominently increased levels of circulating TCR gamma
       delta+ lymphocytes. Successive measurements of circulating TCR gamma
       delta+ lymphocytes demonstrated the persistence of increased levels of
       circulating TCR gamma delta+ lymphocytes. We divided the patients with
       sarcoidosis into two groups, one with high, the other with low TCR gamma
       delta+ expression. Compared with the low-value group, the high-value
       group had significantly decreased levels of circulating CD4+
       lymphocytes, decreased incidence of a positive tuberculin reaction, and
       higher levels of serum angiotensin-converting enzyme and lysozyme,
       suggesting that these two groups may differ in their immunological
       response and disease activity of sarcoidosis. Measurement of TCR gamma
       delta+ expression in the circulation seems to be useful for estimating
       the disease activity of sarcoidosis.
 DE    Adolescence  Adult  Aged  Child  CD4 Lymphocyte Count  Female  Human
       Lymphocytes/*IMMUNOLOGY  Male  Middle Age  Receptors, Antigen, T-Cell,
       gamma-delta/*ANALYSIS  Sarcoidosis/*IMMUNOLOGY  Support, Non-U.S. Gov't
       Tuberculin Test  JOURNAL ARTICLE

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