Document 0043
 DOCN  M9590043
 TI    Comparison of the antiviral activities of 3'-azido-3'-deoxythymidine
       (AZT) and gossylic iminolactone (GIL) against clinical isolates of
       HIV-1.
 DT    9509
 AU    Royer RE; Mills RG; Young SA; Vander Jagt DL; Department of
       Biochemistry, University of New Mexico School of; Medicine, Albuquerque
       87131, USA.
 SO    Pharmacol Res. 1995 Jan;31(1):49-52. Unique Identifier : AIDSLINE
       MED/95303755
 AB    3'-Azido-3'-deoxythymidine (AZT) and gossylic iminolactone (GIL) were
       compared for antiviral activities in vitro against fresh clinical
       isolates of HIV-1 obtained from 19 subjects on AZT therapy. IC50 values
       for AZT ranged from 0.015 to 6.7 microM (447-fold range) while IC50
       values for GIL ranged from 0.40 to 6.6 microM (16-fold range). There was
       no correlation between IC50 values for AZT and GIL, suggesting that the
       anti-HIV activity of GIL does not involve inhibition of reverse
       transcriptase.
 DE    Acquired Immunodeficiency Syndrome/VIROLOGY  Antiviral
       Agents/PHARMACOLOGY  Comparative Study  Dose-Response Relationship, Drug
       Gossypol/*ANALOGS & DERIVATIVES/CHEMISTRY/PHARMACOLOGY  Human
       HIV-1/*DRUG EFFECTS/ENZYMOLOGY  Reverse Transcriptase/ANTAGONISTS &
       INHIB  Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.
       Zidovudine/CHEMISTRY/*PHARMACOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).