Document 0051
 DOCN  M9590051
 TI    Cytokine-producing cells in experimental autoimmune encephalomyelitis
       and multiple sclerosis.
 DT    9509
 AU    Olsson T; Department of Medicine, Karolinska Hospital, Stockholm,
       Sweden.
 SO    Neurology. 1995 Jun;45(6 Suppl 6):S11-5. Unique Identifier : AIDSLINE
       MED/95303307
 AB    In both multiple sclerosis (MS) and experimental autoimmune
       encephalomyelitis, the regulation of the cytokine spectrum and
       production is likely to have a decisive influence on disease outcome.
       Studies of cytokines, however, are hampered by the autocrine or
       paracrine nature of cytokines. Studies of cellular production by
       messenger RNA detection or cellular secretion are therefore necessary.
       Collective data suggest that certain cytokines associated with the TH1
       phenotype or lymphocytes, such as tumor necrosis factor alpha,
       lymphotoxin, interleukin-12, and interferon gamma, may promote disease,
       while cytokines produced by the TH2 subset, such as interleukin-10, may
       limit disease. In addition, transforming growth factor beta is a
       putative disease downregulator. Increased knowledge in this field will
       likely lead to improved therapy for MS patients.
 DE    Cytokines/GENETICS/*METABOLISM  Encephalomyelitis,
       Allergic/*METABOLISM/*PATHOLOGY  Human  Interferons/GENETICS/METABOLISM
       Interleukins/GENETICS/METABOLISM  Multiple
       Sclerosis/*METABOLISM/*PATHOLOGY  RNA, Messenger/METABOLISM  Th1
       Cells/*METABOLISM  Th2 Cells/*METABOLISM  Tumor Necrosis
       Factor/GENETICS/METABOLISM  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).